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A randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate cardiovascular outcomes during treatment with lixisenatide in type 2 diabetic patients after an Acute Coronary Syndrome event

The primary objective of this phase III study is to demonstrate that lixisenatide can reduce cardiovascularmorbidity and mortality (composite endpoint of cardiovascular (CV) death, non-fatal myocardialinfarction (MI), non-fatal stroke,…

Efficacy and safety of semaglutide once-weekly versus exenatide ER 2.0 mg once-weekly as add-on to 1-2 oral antidiabetic drugs (OADs) in subjects with type 2 diabetes.

To compare the effect of semaglutide 1.0 mg once-weekly versus exenatide extended release (ER) 2.0 mg once-weekly on glycaemic control after 56 weeks of treatment.

Off taRget Effects of Linagliptin monothErapy on Arterial Stiffness in Early diabetes

1. To assess whether linagliptin compared with placebo improves arterial stiffness in treatment naïve subjects with type 2 diabetes.2. To assess whether linagliptin compared with placebo improves blood pressure parameters, inflammatory and…

HypoAware: A combined group and online educational program for diabetes patients with problematic hypoglycemia. A cost-effectiveness Randomized Controlled Trial.

To test the cost-effectiveness of the psycho-educational intervention HypoBewust (HB) compared to care as usual.Research questions:1) Does HB significantly improve a) health related outcomes and b) societal costs after 6 months?2) Are the expected…

Nurse-directed versus algorithm-assisted Tight Blood Glucose Control in adult critically ill patients: the LOGIC-2 multi-centre randomized controlled trial

The primary objective of the study is to demonstrate the effectiveness of the computer algorithm (LOGIC-Insulin) against the standard routine protocol for the normalisation of blood glucose concentrations in the ICU.The secondary objective of the…

Efficacy of Laparoscopic Roux-en-Y Gastric Bypass Surgery versus Conventional Therapy for Type 2 Diabetes Mellitus in Moderate Obese Patients with BMI of 30 -35 kg/m2: a randomized controlled trial.

We hypothesize that laparoscopic RYGB surgery is more effective on glycaemic control than conventional therapy in moderate obese patients with BMI 30 * 35 kg/m2 .

Interactive exercise therapy at home:
a web based solution to improve long-term adherence, self-management and clinical efficacy of a life-style intervention program for patients with Type 2 Diabetes

Primary Objectives: - DirectLifeDirectLifeAre the LiveWorkout® and DirectLife® concept feasible web based training programs for type 2 diabetes patients ?- How do type 2 diabetes patients experience web based training intervention programs ? What…

Efficacy and safety of semaglutide once weekly versus insulin glargine once daily as add on to metformin with or without sulphonylurea in insulin-naïve subjects with type 2 diabetes

To compare the effect of once-weekly dosing of two dose levels of semaglutide versus insulin glargine once-daily on glycaemic control after 30 weeks of treatment in insulin-naïve subjects with type 2 diabetes.

The effects of galactooligosaccharide (GOS) on peripheral insulin sensitivity and body weight control in obese adults with impaired glucose homeostasis

Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…

The efficacy and safety of liraglutide adjunct to insulin treatment in type 1 diabetes;
A 26-weeks randomised, insulin capped, placebo-controlled, double-blinded, parallelgroup, multinational, multi-centre trial

To confirm superiority of liraglutide compared to placebo, both adjunct to insulin treatment, on glycaemic control, after 26 weeks of treatment in subjects with established type 1 diabetes in inadequate glycaemic control.

A randomized, double-blind, placebo-controlled study in two parts to investigate in Part 1 the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending dose of RO6799477 in healthy volunteers, and in Part 2 the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple dose of RO6799477 in patients with type 2 diabetes mellitus.

Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…

The effect of continuous glucose monitoring on glycaemic control in patients undergoing major surgery

Our objectives are to evaluate whether CGM improves perioperative glycaemic control.

'Glycemic control for people with diabetes after three months of information about nutrition and feedback about physical activity behaviour'

The primary aim of the present research is to determine if a digital health program, with information about nutrition/physical activity/diabetes and feedback on physical activity behaviour by an activity tracker leads to improvement of glycemic…

Effects of timing of food intake on glucose metabolism and the brain during a hypocaloric diet in obese subjects

To investigate whether in obese subjects meal timing during a hypocaloric diet is related to the brain serotonergic system and insulin sensitivity as well as to food-motivated behavior.

Effects of GLP1 agonist liraglutide in patients with antipsychotic-drugs-associated diabetes mellitus

1. To assess the efficacy of liraglutide in patients with schizophrenia and diabetes ona. Glycaemic controlb. Body weightc. Cardiovascular risk factors (blood pressure, lipids)2. To assess the safety of liraglutide in these patients3. To assess the…

After the Health Check in vulnerable groups: an individually tailored self regulation intervention led by Community Health Workers.

The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…

Better Accepance of a Singe injection Apidra (insulin glulisine) Added to once daily Lantus (insulin glargine) versus twice daily Premixed insulin in a real Life Use Setting.

The objective of this observational, randomized study is to examine the efficacy, safety and patient acceptance of the basal plus insulin regimen (i.e. one injection rapid acting insulin glulisine at the main meal added to once daily basal insulin…

Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with a recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2D)

To determine whether aleglitazar reduces cardiovasculair mortality and morbidity (defined as non-fatal myocardial infarction (MI) and non-fatal stroke) in patients with a recent ACS event and type 2 diabetes.

Improving preconceptional suboptimal glycaemic control in type 1 diabetes using RealTime Continuous Glucose Monitoring: a randomised trial

This study is designed to investigate whether it is possible to achieve substantial improvement of HbA1c values in preconceptional suboptimal regulated type 1 diabetes mellitus (which is HbA1c 7.0-7.7%). Primary outcome- Absolute reduction in…

DALI: Vitamin D and Lifestyle Intervention for GDM Prevention: dosing study

The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…