261 results
The objective of the current study is to investigate the efficacy and safety of BI 10773 (10 and 25 mg) compared to placebo on glucose control and bloodpressure over 12 weeks in hypertensive patients with diabetes mellitus type 2.
Our pragmatic trial aims to integrate a cost-effective innovative care intervention in regular primary care. The intervention needs to be adapted for practice nurses to detect mental health problems in physical chronic patients and to provide,…
To compare the efficiency and safety of Continuous subcutaneous glucose monitoring compared to our standard care (bloodsamples obtained from an arterial or venous bloodsample and measured by the AccuChek.
1. Measurement of the 24-hour glycemic profile in response to acute submaximal hypoxic and hyperoxic exercise in order to determine its effectiveness and select the most efficient method in reducing post-exercise hyperglycemia prevalence in…
To determine non inferiority of two doses of BI 10773 (10 mg/daily and 25 mg/daily) compared to placebo with respect to first occurrence of any of the adjudicated components of the primary composite Major Adverse Cardiovascular Event endpoint (…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
Primary objectives1. To determine the change in HbA1c from baseline and end of treatment after 26 weeks of treatment with liraglutide versus liraglutide with NEAT2. To determined the change in weight from baseline and end of treatment after 26 weeks…
Our primary objective is the effect of taurine on morbidity and consequent mortality.
Primary objective:To assess the effects of fenretinide on hepatic and peripheral insulin sensitivity in obese, insulin resistant subjectsSecondary objective:To assess the effects of fenretinide on hepatic steatosis, body weight and body fat…
the purpose of this study is to investigate the efficacy of liraglutide to lower glucose and to influence coagulation activation during and after hip surgery
Objective: this study aims to investigate whether SDM may increase the amount of T2DM patients who reach the individualised T2DM treatment targets (blood pressure, total cholesterol, HbA1C, weight and smoking status).
To investigate whether the in vivo postprandial muscle protein synthetic response is augmented when dietary nitrate ingestion precedes protein ingestion in elderly type 2 diabetics.
To confirm superiority on glycaemic control of liraglutide versus placebo after 26 weeks of treatment when added to pre-existing basal insulin analogue treatment (with or without concomitant metformin treatment) in subjects with type 2 diabetes.
Primary objective: to confirm the efficacy of insulin degludec administered once daily plus mealtime insulin aspart in controlling glycaemia with respect to change from baseline in HbA1c after 26 weeks of treatment. Secundary objective: to compare…
To investigate whether single dosis of fecal therapy by infusion of allogeneic (post bariatric surgery donor feces in the bowel) or autologous (own feces) have differential effect on lipid-metabolism-mediated insulin resistance.
We will examine the feasibility of an experimental condition- in which either a passive or active school morning is simulated- to test the effect of physical activity on cognition and cardiovascular health in children. In addition, we will gather…
To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.
To confirm the efficacy of liraglutide as adjunct to insulin treatment on glycaemic control, and toconfirm the superiority of liraglutide treatment compared to placebo, both adjunct to insulintreatment, with regard to reduction in daily insulin dose…
The main objective is to explore the effects of a 10-day fasting and exercise program on body composition and physical performance (peak power, endurance capacity, efficiency and resting VO2¬) of overweight, fit men and compare these effects with…