261 results
This study aims to test the effectiveness and appreciation of a web-based cognitive behavioural therapy (CBT) program for adult diabetic persons with minor to moderately severe depression in a randomized controlled trial.
To identify the relative risk of ME following cataract surgery in patients with DM type 2 and mild to moderate non-proliferative diabetic retinopathy, compared to diabetics type 2 not undergoing cataract surgery.
There is no formal research hypothesis for this study. The purpose is to evaluate the effects of dapagliflozin on kidney function (GFR) and the changes from baseline in the ambulatory Blood Pressure. The effects of dapagliflozin on red cell mass and…
The main parameter of the study is evaluation and effectiveness of the treatment program on Body Mass Index (BMI) (as defined by Cole et al) compared to a standard intervention (increased physical activity and nutrient advice). Also the…
To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.
The primary objective of the study is to demonstrate non-inferiority of an insulin regimen using insulin glargine as the basal insulin with Exubera as the mealtime insulin, compared to a regimen using insulin glargine as the basal insulin and…
To examine the safety, tolerability, and effect on glucose metabolism of metformin treatment in non-diabetic patients with TIA or minor ischemic stroke and impaired glucose tolerance.
The objective of the study is to assess the effects and cost-effectiveness of a cognitive behavior intervention in people at risk for CVD or DM2.
The major research objective is:Does a switch from a low-fat to a high-fat diet lead to a reduced hepatic and skeletal muscle insulin sensitivity due to an increase lipid accumulation in liver, skeletal muscle and heart? Secondary research…
To optimize glycemic control in acute ischemic stroke patients.
To determine whether the generally recommended three-monthly follow up in the usual diabetes care in general practice can be reduced to six-monthly follow up for some of the patients.
To evaluate the effect and costs of a RYGB vs conventional therapy as glucoregulatory treatment for DM2 patients with a BMI>35 kg/m2 and HbA1c >7% despite 2 blood glucose lowering agents (not being insulin).
to confirm that GMC 252 is absorbed in humansto determine in humans whether GMC 252 is cleaved, yielding diflunisal and N-acetylcysteine (NAC)to determine whether additional metabolites are formed with GMC-252 compared with diflunisal and NAC
The purpose of the study is to confirm the skin test results in patients based on results of the control population of healthy volunteers never exposed to taspoglutide or any product with a similar mechanism of action.
To assess whether supplemention of vitamin D3 (1200 IU/day) in vitamin-D deficient non-western immigrants at risk for type 2 diabetes mellitus can improve the insulin resistance and betacell function as well.
This research project aims to investigate whether hyperoxic interval training improves whole body insulin resistance, endothelial dysfunction, cardiovascular fitness, lipid metabolism and glycemic control in the treatment of deconditioned non-…
To investigate the effects of colesevelam (bile acid sequestrant) on bile acid composition, glucose metabolism and composition of faecal flora in patients with an impaired glucose tolerance or newly diagnosed type 2 diabetes
Objective is to study the implementation of a proven cocept for active primary prevention of type 2 diabetes in a Dutch primary care setting, in order to assess whether such a concept can be applied on a broader scale, and as such contribute to the…
The objective of these studies is to identify the primary mechanisms of GC-induced dysmetabolic effects in humans and to find biomarkers that reflect these side effects of GC treatment and which can be followed during therapy and in future clinical…
Primary:To evaluate the safety of a single subcutaneous injection of ISIS 325568 administered at four increasing dose levels (50, 100, 200, 400 mg/week) and to evaluate the safety and tolerability of multiple doses of ISIS 325568 (three intravenous…