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Dietary treatment of children with Angelman Syndrome and refractory epilepsy

Primary objective: - 50% seizure reduction or more at 3 months of dietary treatment .Secondary objectives: -level of ketosis on KD and MAD.-number of patients maintaining >50% seizure reduction on MAD.-number of withdrawals (not able to…

Perioperative Transfusion Study (PETS): does a liberal transfusion protocol improve outcome in high-risk cardiovascular patients undergoing non-cardiac surgery?

The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…

A Study Assessing The Effect Of A Structured Medication Review On Quality Of Life In Patients With Parkinson*s Disease*

The aim of this study is to assess whether a structured medication review in primary care improves medication adherence and leads to positive patient outcomes in patients with PD. The expectation is that the results of this study might be used to…

Metformin and sitagliptin in patients with impaired glucose tolerance and a recent TIA or minor ischemic stroke - safety and feasibility

We aim to compare the effectiveness, feasibility and safety of both metformin and sitagliptin in patients with TIA or minor ischemic stroke and impaired glucose tolerance. Furthermore, we will assess whether a slow increase in dose of metformin over…

Multi Sensory Stimulation And Priming (MuSSAP) in infants (4-12 months of age) at risk of developing Unilateral Cerebral Palsy (UCP).

Primary objective:The following hypothesis will be tested:MuSSAP in infants 4-12 months of age with diagnosed unilateral cerebral damage, is a feasible protocol and results in an enhanced motor development as compared to Intensive Usual Care (Upper…

Ultra low-dose chest ct with iteratIve reconstructions as an alternative to conventional chest x-ray prior to heart surgery

To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT reconstructed with IR lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared…

Efficacy of vitamin D supplementation in preventing peripheral neuropathy in multiple myeloma patients.

The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.

HOMERUN
Initiation of HOme MEchanical ventilation at home in a selective group of patients with chronic hypercapnic Respiratory failUre in the Netherlands

Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…

TimeToStop (TTS) Trial, A randomized controlled trial of cognitive consequences of early versus late antiepileptic drug withdrawal after pediatric epilepsy surgery

Primary Objective: To assess whether early postoperative AED withdrawal improves cognitive function compared to late withdrawal.Secondary objectives: * To confirm safety of earlier AED withdrawal; we will assess eventual seizure freedom, seizure…

Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care

Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…

A multicentre, randomised, controlled, clinical Investigation of a standalone decision support Algorithm for Neonatal Seizure Recognition

The primary objective of this investigation is to assess the performance of the ANSeR Software System by quantifying and comparing the diagnostic accuracy of investigation personnel using the ANSeR Software System with the diagnostic accuracy of…

Partial sleep deprivation in long-term video-EEG monitoring

To assess the provoking effect of partial sleep deprivation on paroxysmal neurological events in a EMU setting, in people with possible epileptic seizures.

Neuralgic amyotrophy: Central reorganization and rehabilitation after peripheral dysfunction

Primary Objectives: * To determine if NA patients have altered cerebral activity related to motor planning of their affected arm compared to healthy controls and compared to their non-affected arm.* To determine if specific rehabilitation focused on…

Managing Thrombocyte transfusions in a Special Subgroup: NEonates

To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.

Effects of temporary discontinuation of antihypertensive treatment in older patients with cognitive impairment: a randomised controlled trial.
The DANTE Study Leiden, Discontinuation of ANtihypertensive Treatment in the Elderly

To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.

Safeguarding the brain of our smallest children ;* an investigator-initiated randomised, blinded, multinational, phase II
feasibility clinical trial on near-infrared spectroscopy monitoring
combined with defined treatment guidelines versus
standard monitoring and treatment as usual in premature infants

The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…

Effect of a PReoperative Information Video on Anxiety in Deep Brain Stimulation surgery patients

Our aim is to investigate whether patients who are informed by video will have less preoperative anxiety than the patients who receive usual information.

The modified Atkins diet in patients with refractory epilepsy and severe intellectual disability: a randomized controlled trial.

The main objective is to evaluate the effect of the modified Atkins diet on the seizure frequency of institutionalized adults with refractory epilepsy and severe intellectual disability.

Neurogenic bladder in children: use of feed-back tools during standard treatment with anticholinergics.

We aim to increase patient compliance by extending the existing treatment protocol of (oral or intravesical) anticholinergics plus application of CIC with the addition of bladder pressure measurement performed at home during CIC plus access to an…

Controlled Study on the Effectiveness of a Dutch Can Do Training (CDT) in People with Relapsing Remitting Multiple Sclerosis

To investigate the effect of a Dutch Can Do Training (CDT) on self-efficacy in people with Relapsing Remitting Multiple Sclerosis.