70 results
To evaluate the effect of AMG 334 compared to placebo on the change from baseline in mean monthly migraine days, in subjects with episodic migraine.hypothesis: In subjects with episodic migraine, AMG 334 has a greater reduction from baseline in mean…
The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…
investigate whether early treatment with ChEI delays the progression of minor VH to major VH without insight or PDP. In addition, we will measure motor control, psychotic symptoms, cognitive impairment, mood disorders, adverse events and compliance…
The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.
In this research project we explore anti-nociception as a state of pain modulation. Our main objectives in utilizing the plasticity of the central pain pathways are to: (i) Shift individuals from a pro-nociceptive pain modulation profile to an anti-…
The aim of this study is to examine the daily level of activities and participation after LTH in children and adolescents (6-18 years) and to identify possible predictors. In addition, experimental research is done in a subgroup to measure the…
To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.
The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…
Our aim is to investigate whether patients who are informed by video will have less preoperative anxiety than the patients who receive usual information.
The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.
Primary objectives: 1. Does vitamin D supplementation improve depressive symptoms in older persons? 2. Does vitamin D supplementation improve physical performance and functional limitations in older persons?Secondary objectives: 3. Does vitamin D…
To evaluate the effect of surgical decompression of the nerves in the lower extremities in patients with painful diabetic neuropathy.
To determine the best dose escalation scheme of dipyridamole added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke
1) To evaluate the efficacy of knee-ankle-foot orthoses (worn by night) in preventing a decrease of range of motion to ankle dorsiflexion in children with cerebral palsy (Clinical part). 2) To evaluate the effect of night-worn knee-ankle-foot…
The present PhD thesis focuses on the investigation of ADAS and the older driver. Even though, recent research investigated the effects of ADAS on driving performance, little is known about the long-term effects of the systems on performance.…
The objective of the study is to investigate the effects of bright light combined with physical activity during the morning on subjective and objective outcomes related to sleep-wake cycle and the rest-activity rhythm in persons with MCI, aged 65…
To evaluate whether preventive treament with haloperidol lowers the risk for delirium in stroke patients with an increased risk for delirium.
To show whether Active C disc prosthesis is more effective than anterior discectomy with or without interbody fusion 1 year after surgery. Moreover, the incidence of adjacent disc degeneration will be evaluated 5 years after surgery.
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care, under supervision of a specialized physiotherapist can prevent the frequently observed decline in global…
The general aim of this project is to evaluate the effectiveness, safety and costs of a medication withdrawal policy compared to usual care in general practice in patients who are currently treated for hypertension and/or hypercholesterolemia, but…