Search for a trial

Care4Stroke+ program: Caregiver mediated exercises with e-health support for early supported discharge after acquired brain injury.

The primary aim of this study is to evaluate the feasibility, clinical effectiveness and cost effectiveness of a caregiver mediated exercises programme combined with e-health services (CARE4STROKE+) to improve self-reported health status and reduce…

Metformin and sitagliptin in patients with impaired glucose tolerance and a recent TIA or minor ischemic stroke - safety and feasibility

We aim to compare the effectiveness, feasibility and safety of both metformin and sitagliptin in patients with TIA or minor ischemic stroke and impaired glucose tolerance. Furthermore, we will assess whether a slow increase in dose of metformin over…

A randomized, double blind, placebo-controlled single ascending dose study on the safety, tolerability, pharmacokinetics and pharmacodynamics of ACT017 in healthy volunteers

PRIMARY OBJECTIVETo evaluate the safety and tolerability of single ascending, intravenous doses of ACT017 administered as a 6-hour intravenous (i.v.) infusionSECONDARY OBJECTIVES* To evaluate the pharmacokinetics of single ascending, intravenous…

Efficacy and safety of MRI-based thrombolysis in wake-up
stroke: a randomised, double-blind, placebo-controlled trial

The ,aim of Wake-Up is to provide a new safe and effective treatment option for acute stroke patients waking up with stroke symptoms or patients with unknown symptom onset. Every year about 2milion patients suffer a stroke in the EU and up to 20% of…

Explaining plasticity after stroke

EXPLICIT aims tot obtain better functional outcome by early intensive rehabilitation. Next to clinical tests to measure improvement in function, neuroplasticity is assessed by fMRI, TMS and haptic robots. The combination of clinical outcome measures…

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 18-Month Safety and Efficacy Study of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Mild Alzheimer*s Disease

1. To demonstrate the clinical efficacy of leuco-methylthioninium bis(hydromethanesulfonate) (also known as LMTM,TRx0237) in mild Alzheimer*s disease as assessed by change from baseline on:• Alzheimer*s Disease Assessment Scale - Cognitive Subscale…

Computer based cognitive flexibility training after stroke

In this study the effectiveness of online cognitive flexibility training on cognitive functioning in stroke patients will be investigated. The aim of this study is to improve executive functions: both trained executive functions as well as untrained…

A PHASE 2, RANDOMIZED, DOUBLE BLIND PLACEBO CONTROLLED TRIALTO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND EFFICACY OF PF-04360365 (PONEZUMAB) IN ADULT SUBJECTS WITH PROBABLE CEREBRAL AMYLOID ANGIOPATHY

Primary Objective:- To evaluate the efficacy of PF-04360365 (ponezumab) in subjects with probableCAA as compared to placebo on a BOLD fMRI measure of cerebrovascularreactivity.Secondary Objectives:- To evaluate the efficacy of PF-04360365 (ponezumab…

The efficacy of C-Mill training for improving walking ability, walking speed and gait adaptability in people post stroke: a single-centre RCT

The main objective of the proposed study is to examine the relative efficacy of C-Mill gait adaptability treadmill training compared to the Nijmegen Falls Prevention Program (NFP program) for improving walking ability aspects, particularly walking…

Feasibility of Supervised Care & Rehabilitation Involving Personal Tele-robotics for arm/hand function of chronic stroke patients

The primary objective of this study is to examine user acceptance and assess changes in arm function by people with chronic stroke following technology-supported arm/hand training at home. Secondary objectives are to examine whether stroke patients…

Late LTP-like plasticity effects of tDCS in subacute stroke patients

Identify the effect of late LTP-like plasticity on motor rehabilitation during the subacute phase after stroke.

Late LTP-like plasticity effects of tDCS in chronic stroke patients

Identify the effect of late LTP-like plasticity tDCS in chronic stroke patients on skill learning 24 hours later.

Multi Center Clinical trial of endovascular treatment of acute ischemic stroke in the Netherlands.

The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…

Treatment of obstructive sleep apnea and rehabilitation outcome in stroke

In this study the relation of OSAS with functional status and cognition, and the effect of treatment with CPAP on outcomes of rehabilitation in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between…

INTERVENTIONAL MANAGEMENT OF STROKE TRIAL CLINICAL PROTOCOL - IMS III
A phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (Activase®/Actilyse®) alone when initiated within three hours of acute ischemic stroke onset.

The primary objective of the trial is to determine if ischemic stroke subjects with a baseline NIH Stroke Scale Score (NIHSSS] >= 10 (8-9 with positive CTA) treated with recombinant tissue plasminogen activator (rt-PA; [Alteplase recombinant…

The second INTEnsive blood pressure Reduction in Acute Cerebral haemorrhage Trial. An international randomised controlled trial to establish the effects of early intensive blood pressure lowering in patients with intracerebral haemorrhage.

To establish the effects of a management policy of early intensive BP lowering on death and disability inpatients with acute spontaneous, primary, ICH and co-existing elevated BP compared to a moreconservative BP management policy that is based on a…

Gait training of chronic stroke patients in the gait rehabilitation device LOPES

Primary: - What are the effects of gait training with the gait rehabilitation device LOPES on the quality and ability of walking in chronic stroke patients with a stiff-knee gait?- What are the effects of two different training modes in the gait…

Induced hypertension for delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage: a feasibility study

To assess the feasibility of a randomized clinical trial on induced hypertension, and to assess whether the studied intervention is effective in increasing CBF.

A randomized, controlled, open-label, parallel-group, multi-center study to compare the effect of Intrathecal Baclofen Therapy (ITB Therapy®) versus Best Medical Treatment (BMT) on spasticity in post-stroke patients after 6 months active treatment

The objective is to determine whether ITB Therapy is more effective than oral anti-spasticity agents in reducing the spasticity.

Induced hypertension for treatment of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage.

To investigate the outcome after induced hypertension versus no induced hypertension in patients with DCI after aneurysmal SAH.