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HOMERUN
Initiation of HOme MEchanical ventilation at home in a selective group of patients with chronic hypercapnic Respiratory failUre in the Netherlands

Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…

Initiation of chronic ventilatory support outside the hospital.

We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…

Functional imaging of Brain-Computer Interface control

There are some unresolved issues that we intend to address in this project. We will examine 1) whether with locating the motorcortex with functional MRI, the best location of the electrodes can be predetermined, 2) how brain activity changes in the…

A First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of DNL104 in Healthy Subjects

- Investigate the safety and tolerability of single ascending doses of DNL104 in healthy volunteers.- Characterize the pharmacokinetics of DNL104 in plasma, CSF, and urine.- Characterize the effect of a high fat meal on the pharmacokinetics of…

The ironHand system integrates both support in ADL and functional training exercises to improve impaired hand function

The primary objective of the present study is to examine the orthotic and therapeutic effect of the ironHand (iH) system, consisting of both an assistive and therapeutic module, by elderly and diagnosed patients with hand function problems, after…

An open-label, randomized, single center, adaptive, parallel group study to investigate the single dose oral pharmacokinetics (PK) properties of olesoxime formulated as an oral suspension and as an oral solution in the fed state

The study will be performed in 2 parts, Part 1 and Part 2). The purpose of the study is to investigate how quickly and to what extent Olesoxime is absorbed and eliminated from the body. In addition, it will be investigated how safe Olesoxime is and…

Lifebalance; an important outcome for fatigue management in neuromuscular diseases

Primary objective: To evaluate effectiveness, directly after intervention, of an individual face to face Managing Fatigue program on participation for people with NMD, including FSHD or MM compared to a control group receiving usual care.Secondary…

A Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of pegcetacoplan in subjects with amyotrophic lateral sclerosis (ALS)

The primary objective of this study is to assess the efficacy of twice per week subcutaneous (SC) doses of pegcetacoplan 1080 mg compared toplacebo in subjects with sporadic ALS as measured by the Combined Assessment of Function and Survival (CAFS)…

A Randomized, Controlled, Open-Label, Rater-Blinded, Phase 3b Study of the Efficacy, Safety, and Tolerability of 6-Week Extended Interval Dosing (EID) of Natalizumab (BG00002) in Subjects With Relapsing-Remitting Multiple Sclerosis witching From Treatment With 4-Week Natalizumab Standard Interval Dosing (SID) in Relation to Continued SID Treatment - Followed by an Open-Label Crossover Extension Study Comprising Subcutaneous and Intravenous Natalizumab Administration

Part 1: The primary objective of this study is to evaluate the efficacy of natalizumab extended interval dosing (EID) in subjects who have previously been treated with natalizumab standard interval dosing (SID) for at least 12 months, in relation to…