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Cervical radicular pain: A randomised controlled trial comparing percutaneous plasma discectomy and anterior cervical discectomy.

The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…

Dexmedetomidine versus propofol in the awake implantation of a neuromodulative system.

The purpose of this study is to observe the usability of dexmedetomidine compared to the standard therapy (propofol) and to determine the overall satisfaction of the patient.

Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care

Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…

Study of Safety, Tolerability, and Pharmacokinetics of BG00010 (Neublastin) Intravenous and Subcutaneous Single Ascending Doses in Healthy Volunteers, and Subcutaneous Multiple Ascending Doses in Subjects with Painful Lumbar Radiculopathy

The primary objective of the study is to evaluate the safety and tolerability of a range of single IV and SC doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in subjects with painful lumbar radiculopathy.Secondary…

A Multi-Centered, Randomized, Blinded, Placebo-Controlled, Serial-Cohort, Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of BG00010 (Neublastin) in Subjects with Sciatica

The primary objective of the study is to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of 3 intravenous (IV) injections of BG00010 given on 2 fixed schedules; weekly and as frequently as every 48 hours (but no more than 3 times…

The effects of hybrid cycle exercise training in inactive people with a chronic spinal cord injury.

The primary objective is to evaluate the short- and long-term effectiveness of a hybrid cycle training program on physical capacity, active lifestyle, participation, and quality of life among a group of inactive individuals with a chronic SCI.…

A randomised, sham-controlled, double-blind, multicenter clinical trial to evaluate the percutaneous pulsed radiofrequency treatment at the dorsal root ganglion

investigate the value of percutaneous pulsed radiofrequency, applied to the lumbar and sacral dorsal root ganglion; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-operated…

The effect of 16-week low-intensity wheelchair training on functions, activities, and participation in inactive people with a spinal cord injury.

The primary objective is to evaluate the effectiveness of low-intensity hand rim wheelchair exercise training on physical capacity, daily (wheelchair) functioning, participation and quality of life in people with a spinal cord injury. Furthermore,…

Percutaneous Cervical Nucleoplasty vs. Pulsed Radio Frequency in patients with contained cervical disc herniation; a double-blind randomized clinical trial

To investigate which technique is the most effective in terms of pain relief on short term in patients with contained cervical disc herniation: PCN or PRF?

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

Promoting physical activity in individuals with spinal cord injury

The general objective of this project is to evaluate, for persons with a SCI, on the short and long term, the added value of a behavioural focused intervention, on top of a physical exercise intervention, on the level of everyday physical activity.…

Cost-effectiveness of nerve root decompression according to Gill versus instrumented fusion in the treatment of spondylolytic spondylolisthesis; a multicenter prospective randomised trial.

The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…

Intrathecal methylprednisolone for intractable postherpetic neuralgia.

To measure the effectiveness of intrathecal methylprednisolone and lidocaine on reducing PHN. Measurement of mthylprednisolone concentrations in cerebrospinal fluid (Part I only).

Intrathecal methylprednisolone for intractable postherpetic neuralgia.

To measure the effectiveness of intrathecal methylprednisolone and lidocaine on reducing postherpetic neuralgia. Measurement of intrathecal methylprednisolone concentrations.

Effectiveness of Inspiratory Muscle Training on respiratory function and patient functioning in persons with Spinal Cord Injury

Evaluate the effectiveness of Inspiratory Muscle Training (IMT) during primary rehabilitation on pulmonary function and respiratory muscle strength in persons with SCI. Also, we will explore the long-term effectiveness on respiratory complications…

A placebo-controlled, randomized, safety and efficacy study of BOTOX® (Bolulinum Toxin Type A) Purified Neurotoxin Complex in patients with neurogenic detrusor overactivity and neurological respiratory impairment.

To evaluate the safety and efficacy of 2 dose levels of BOTOX® (200 U or 300 U) compared to placebo injected into the detrusor for the treatment of urinary incontinence caused by neurogenic detrusor overactivity in patients who have not been…

Study of the analgesic effects of repeated doses of F13640 in spinal cord injury patients with moderate to severe central neuropathic pain.
A multinational, multicenter, randomized, double blind, parallel groups, placebocontrolled
study.

Primary objective:To evaluate the efficacy of F13640 in spinal cord injury patients with moderate to severe central neuropathic pain, when administered for 12 weeks including a 7-day titration period. Main secondary objectives:To evaluate pain…

The efficacy of the IDD-protocol with Accu-Spina for patients with low back pain

The primary objective of the study is to investigate whether the IDD (Intervertebral Differential Dynamics) protocol with Accu-Spina on the VAS low back pain score at 3 months posttreatment.

Multidisciplinary behavioural program for coping with chronic neuropathic pain following spinal cord injury.

To evaluate a group treatment program to stimulate effective coping with chronic neuropathic pain following spinal cord injury.

The CHARACTER SCS Study: A randomised pilot study to assess differenCes in tHe subjects* experience of stimulAtion-Induced paRaesthesiA between two different spinal Cord sTimulation dEvices: the Axium® DoRsal Root Ganglion Stimulation System Versus the Prime Advanced* Dorsal Column Stimulation System

The principal goal of this study is to compare subjects* experience of Spinal Cord Stimulation (SCS) with two different types of SCS device.