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Complement Inhibition: Attacking the Overshooting Inflammation @fter Traumatic Brain Injury ( A phase II trial on the safety and efficacy of C1 esterase inhibitor Cinryze for the acute management of severe traumatic brain injury)

This study has been transitioned to CTIS with ID 2024-514488-24-01 check the CTIS register for the current data. Primary Objective: To determine the safety and efficacy of 6000 IU Cinryze in patients with moderate and severe TBI (GCS <13 with…

Acetazolamide in Aneurysmal Subarachnoid Hemorrhage

In a phase II study we will evaluate safety and proof-of-concept of acetazolamide in patients with aneurysmal SAH. The primary aim of this study is to evaluate whether acetazolamide improves cerebral perfusion as measured with magnetic resonance…

CPPopt Guided Therapy: Assessment of Target Effectiveness

Main aim: We will assess whether the new intervention protocol provides a greater percentage of time during which CPP is within 5 mmHg of calculated individual and flexible CPP (CPPopt). This window has been chosen based on past studies which show…