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Effects of mannitol and hypertonic saline on cerebral oxygenation and metabolism in patients with posttraumatic intracranial hypertension.

Aim of this study is to compare the effects of mannitol and HS in equimolar concentrations on cerebral blood flow, cerebral oxygenation, metabolism and inflammation in patients with severe TBI.

The effect of intravenous lidocaine to prevent intracranial pressure increase in endotracheal intubation assessed by optic nerve sheath diameter

Primary Objective: To investigate the effect on the distention of the ONSD while using lidocaine 1,5 mg/kg IV during endotracheal intubation versus placebo. Secondary Objectives: The secondary objective of this study is to investigate the effect…