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Induction of labour in hospital with a Foley catheter or oral misoprostol versus induction of labour at home with a Foley catheter or oral misoprostol

Is priming of the cervix, as part of induction of labour:* At home cost-effective and safe compared to the hospital?* with oral misoprostol cost-effective and safe compared to a Foley catheter?

Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: a randomized double blind placebo-controlled comparison (Triple M trial)

This study will compare sequential mifepristone and misoprostol treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.

Helping pregnant women stop smoking with a dual tasking treatment

Specifically, the first objective of the current study is to compare the efficacy of a dual tasking treatment versus treatment as usual in the treatment of smoking addiction in a pregnant population on smoking outcomes. Secondary objectives:Effect…

The TAPS Trial;Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence: a multicenter open label randomized controlled trial

The aim of this trial is to investigate whether fetoscopic laser surgery improves the outcome for TAPS twins as compared to the control group (standard care consisting of expectant management, IUT, preterm delivery). The hypothesis is that…

High versus low initial oxygen to improve the breathing effort of preterm infants at birth

The objective of this study is to compare the direct effect of the administration of an initial FiO2 of 1.0 versus 0.3 on respiratory effort during stabilisation of preterm infants in the first 5 minutes after birth. After evaluation of the initial…

Stabilisation of preterm infants with intact umbilical cord: effectiveness study.

To test whether stabilisation of preterm infants with PBCC using the Concord is at least as effective when compared to the standard approach using the standard resuscitation table.

The Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset intrauterine growth Restriction) Trial

We aim to compare the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival, in women with singleton pregnancies with severe fetal growth restriction of placental origin.

Controlled hypotensive versus massive fluid resuscitation strategy: influence on blood loss and hemostatic parameters in obstetric hemorrhage

In women with early, mild PPH (blood loss 500-750ml) we would like to establish whether restrictive resuscitation strategy reduces the progression to severe PPH (blood loss > 1000 ml) compared to care as usual

Long term effects of multidisciplinary assessment and pre-partum Pelvic Floor Muscle Group Treatment in adult gravid women with stress urinary incontinence compared to care-as-usual: a randomized controlled trial

Objectives.The primary aims of this multicenter randomized clinical trial (RCT) are threefold1. to investigate whether a structured assessment and treatment program of intensive, supervised pre-partum pelvic floor muscle group training (PFMGT)…

Long term effects of multidisciplinary assessment and post partum Pelvic Floor Muscle Group Treatment in women with stress urinary incontinence after vaginal delivery compared to care-as-usual: a randomized controlled trial

The primary objectives of this multicenter randomized clinical trial (RCT) are threefold1. to investigate whether a structured assessment and treatment program of intensive, supervised post partum pelvic floor muscle group training (PFMGT) including…

EMDR in pregnant women with PTSD after childbirth

The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…

Multi-center, randomized non-inferiority trial of early treatment versus expectative management of patent ductus arteriosus in preterm infants.

To investigate whether in preterm infants, born at a GA less than 28 completed weeks, with a PDA (diameter >1.5 mm) an expectative management is not inferior to early treatment with regard to the composite of mortality and/or NEC (Bell stage…

Remote ischemic preconditioning for pain management in labour: a randomized controlled pilot study.

Reduce the need for other analgesia after RIPC by investigating the efficacy of remote ischemic preconditioning on pain during labour.

EMDR in pregnant women with Fear of Childbirth

Main objectieve of this study is if EMDR is an effective treatment for women with FoC. Our hypotheses are that in follow-up measurement compared to the pretreatment-measurement 1) WITHIN the treatment group there will be a decrease in the severity…

Postpartum care 2.0: do flexible distribution and intermission of postpartum care, without extension of hours, have a positive effect on the success rate of breastfeeding, experienced empowerment and quality of care by the mother during and after postpartum period?

The aim of this reseach project is to gain insights into the effects of distribution and intermission of postpartum care hours on the success rate of breastfeeding and the experienced empowerment and quality of care by the mother during and after…

Amnioninfusion or expected management after midtrimester PPROM * what are the long-term effects on offspring*s general health and neurobehavioral development?

The long-term follow-up of the PPROMEXIL-III trial is designed to evaluate the effect of amnioninfusion on offspring*s neurological development, lung function and general health.

Diagnostic test (ReceptIVFity) for recognition of embryo implantation failure in practice.

Does the test influence a couples decision to refrain from further treatment.

TTTS 1 trial: A cluster randomized controlled trial comparing a conservative management and primary laser surgery in stage 1 TTTS.

This study aims to compare two management strategies by an international randomized controlled trial: the first relies on the overall conclusion from the Eurofoetus trial and advocates immediate percutaneous fetoscopic surgery for all stages of TTTS…

SIMPLE III; a randomised controlled non-inferiority trial: best timing for a caesarean section in non-progressing labour;

To compare the currently used Friedman partogram (FP) to the newly developed SIMPLE partogram (SP), based on the normogram of the consortium on Safe Labor, for the diagnosis and treatment of non-progressing labour.

Cost-effectiveness of lifestyle care tailored to pregnant women with obesity during this critical period and window of opportunity in the life course: The HYGEIA randomised controlled trial.

Main objective is to assess the effectiveness of SP+ in an almost real-life setting of a randomised controlled trial (RCT) in 930 women with obesity, using CVMD-score as primary outcome measurement. Secondary aim is to assess the cost-effectiveness…