Search for a trial

Does a program of physical therapy exercises, education and home based walking lead to a change of the activity level at moderate COPD-patients in daily life.

The objective of the study is to find out if the COPD-patient how has followed the physical therapy program has lead to a change in activities in daily life. In primairy usual care is espected that the patient will follow the advice of being more…

Early pulmonary rehabilitation after hospitalisation for acute exacerbation COPD.

Evaluating the effects of early pulmonary rehabilitation on exercise capacity, quality of life and readmission.

The effect of tiotropium-bromide on deep inspiration-induced bronchodilation and airway responsiveness in asthma.

1) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily on the degree of bronchodilation following deep inspiration at a given level of bronchoconstriction.2) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily…

A prospective, randomised controlled, multi-center trial comparing in-hospital treatment and early assisted discharge for exacerbations of Chronic Obstructive Pulmonary Disease (COPD).

Aim of this study is to evaluate the procedure of early assisted discharge is effective and cost-effective compared to regular hospital care.The following research questions are drawn for this:1) Does clinical control, as measured with the Clinical…

Action Plan to enhance self-management and early detection of exacerbations in patients with COPD; a Randomized Controlled Trial

Primary Objective: To evaluate the effectiveness of an individualized AP (initiating early detection of exacerbations and prompt intervention) on recovery of symptom-based Quality of life in the event of an exacerbation. Secondary Objective(s): To…

A Multi-Center, Randomized, Double-Blind, Placebo-Controlled study to investigate the efficacy and safety of 52 weeks treatment with QGE031 s.c. in Asthma Patients not adequately controlled by medium- or high-dose ICS plus LABA with or without OCS

To evaluate the efficacy, safety and tolerability of QGE031 (24 mg, 72 mg, 240 mg s.c. q4w) compared to placebo on top of SoC in atopic patients with asthma.

A multi-center, randomized, double-blind, placebo controlled, parallel group study to compare cessation versus continuation of long-term mepolizumab treatment in patients with severe eosinophilic asthma (201810)

Primary:To evaluate whether patients with severe eosinophilic asthma who have received longterm treatment with mepolizumab (at least 3 years) need to maintain treatment with mepolizumab to continue to receive benefit.Secondary:To assess the safety…

A MULTINATIONAL, MULTICENTRE, RANDOMISED, OPEN-LABEL, ACTIVE-CONTROLLED, 26-WEEK, 2-ARM, PARALLEL GROUP STUDY TO EVALUATE THE NON-INFERIORITY OF FIXED COMBINATION OF BECLOMETASONE DIPROPIONATE PLUS FORMOTEROL FUMARATE PLUS GLYCOPYRRONIUM BROMIDE ADMINISTERED VIA PMDI (CHF 5993) VERSUS FIXED COMBINATION OF FLUTICASONE FUROATE PLUS VILANTEROL ADMINISTERED VIA DPI (RELVAR*) PLUS TIOTROPIUM BROMIDE (SPIRIVA®) FOR THE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

Primary objectives To demonstrate the non-inferiority of CHF 5993 pMDI versus fixed combination of fluticasone furoate/vilanterol plus tiotropium in terms of quality of life (change from baseline in the St. George*s Respiratory Questionnaire [SGRQ]…

Randomised, double-blind, chronic dosing (56 week) placebo-controlled, parallel group, multicentre, phase 3 study to evaluate the efficacy and safety of 2 doses of benralizumab (MEDI-563) in patients with moderate to very severe Chronic Ostructive Pulmonary Disease (COPD) with a history of COPD exacerbations (GALATHEA)

Primary Objective:To evaluate the efficacy and safety of 2 doses of benralizumab in patients with moderate to very severe Chronic Pulmonary Disease (COPD).Secondary Objectives:To evaluate the effect of two doses of benralizumab on:* health status/…

The effectiveness of an Oscillating Positive Expiratory Pressure (OPEP) Therapy on respiratory symptoms in patients with COPD/chronic bronchitis with excess mucus in daily clinical practice

To evaluate the effect of OPEP use on respiratory symptoms in patients with COPD or chronic bronchitis with excess mucus in daily clinical practice.

Inhaler instruction in patients with asthma or COPD: can it be improved?

to investigate the additional value of the use of inhaler specific instruction cards in inhaler education in patients with asthma or COPD.

Does monitored discontinuation of inhaled corticosteroids (ICS) for primary care COPD patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects.

The objective of the study is to investigate whether discontinuation of inhaled corticosteroids (ICS) for patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects…

Bubbling therapy for dysfunctional breathing in difficult to treat asthma - a pilot study

To determine the effect of bubbling therapy on asthma control in patients with difficult to treat asthma and dysfunctional breathing.

Infection prevention and immune modulation by bacterial lysates in patients with asthma: gaining insight into the mechanism of an old therapy

To diminish the number of asthma exacerbations with the regular use of a bacterial lysate.

A Phase 3, 24-Week Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Reslizumab Subcutaneous Dosing (110 mg Every 4 weeks) in Patients with Oral Corticosteroid Dependent Asthma and Elevated Blood Eosinophils

The primary objective of this study is to determine the ability of reslizumab (110 mg) administered subcutaneously (sc) once every 4 weeks to produce a corticosteroid-sparing effect (as demonstrated by percent reduction in daily OCS use) in patients…

The influence of a Pulsating Electrostatic Field (PESF) on oxygen saturation, quality of life and exercise capacity of COPD patients, a single center, double blind, placebo controlled study.

Primary objectives:- improvement of oxygen saturation Secondary objectives:- improvement of quality of life- improvement of exercise capacity- improvement of muscle power- improvement of phase angle- registration of potential short term and long…

An open label, randomised, parallel group clinical study to evaluate the effect of the Connected Inhaler System (CIS) on adherence to Relvar/Breo ELLIPTA therapy, in asthmatic subjects with poor control (study 207040)

Primary:To compare the effect of 6 months use of the CIS on adherence to ELLIPTA maintenance therapy when both the subject and the HCP are supplied with data from the maintenance sensor versus no data supplied to the subject and HCP (Arm 1 vs Arm 5…

Pulmonary RehabIlitation with Nasal-high-flow-support in COPD and Effectiveness: The PRINCE study

To determine the difference in increase in cycle endurance time after PR using NHF oxygen supplementation in patients during both exercise training and night time compared to patients using a conventional oxygen delivery systems.

The feasibility of working memory training in COPD patients and the efficacy on cognitive performance, self-control, and stress response

Investigating the efficacy and feasibility of working memory training in COPD patients on cognitive performance, cognitive stress susceptibility and perception, self-control / impulse control, and adherence to physical activity and dietary…

Long-term inhaled nebulized tobramycin in patients with non-cystic fibrosis bronchiectasis. A randomized placebo controlled trial. The BATTLE study Bronchiectasis And Tobramycin SoluTion InhaLation ThErapy.

The primary outcome of the study is a 50% reduction in exacerbation rate in patients using TIS once daily (OD). Secondary outcome parameters are lung function (FEV1, FVC), QoL (QOL-B), LTRI-VAS, Leicester cough score), bacterial load in sputum and…