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A Randomized, Double-Blind, Placebo-Controlled, 2-Way Crossover, Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Danavorexton in Healthy Subjects Undergoing Opioid-Induced Respiratory Depression

Primary Objective:• To evaluate the safety and tolerability of danavorexton single IV infusion administered in healthy subjects undergoing OIRD.Secondary Objective:• To assess the PK of danavorexton single IV infusion administered in healthy…

The effect of a smartphone app with accelerometer on patients* physical activity: a randomised controlled trial.

The primary objective of this study is to investigate if using Hospital Fit 2.0 as part of the usual care physiotherapy treatment of patients hospitalised at the department of Internal Medicine and the department of Pulmonology in MUMC+ will result…

Peri-operative slow paced breathing - a non-invasive technique to reduce anxiety in breast cancer surgery patients

This study aims to examine the effects of guided slow paced breathing performed at induction of anesthesia in patients undergoing surgery for breast cancer on anxiety, scored by Spielberger's State-Trait Anxiety Inventory, State scale (STAI-S…

CONNected Electronic Inhalers Asthma Control Trial 3 (*CONNECT 3*), a 24-Week Treatment, Multicenter, Open Label, Randomized, Parallel Group Comparison Study of Standard of Care Treatment Versus the Budesonide/Formoterol Digihaler Digital System, to Optimize Outcomes in Adult Patients with Asthma

The primary objective of this study is to demonstrate the effectiveness of the DS compared to the SoC group. The secondary objectives:(#1) is to describe the asthma management actions by HCPs for all patients in both groups. (#2) is to evaluate…

A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)

This study has been transitioned to CTIS with ID 2024-512803-37-00 check the CTIS register for the current data. The aim of this study is to evaluate the efficacy, safety and tolerability of BI 1015550 9 mg BID and 18 mg BID compared to placebo in…

Driving pressure during general anesthesia for minimally invasive abdominal surgery - a randomized clinical trial

The overall objective of this RCT is to determine the effectiveness and long-term outcome of an individualized high PEEP ventilation strategy with recruitment maneuvers compared to a standard low PEEP strategy without recruitment maneuvers. The…

INTELLiVENT*ASV Using Mainstream versus Sidestream End*Tidal CO2 Monitoring* a Randomized Noninferiority Clinical Trial in Cardiac Surgery Patients

The objective of this randomized noninferiority trial is to determine whether INTELLiVENT*ASV with sidestream capnography is noninferior to INTELLiVENT*ASV with mainstream capnography with regard to the percentage of breaths in a broadly accepted…

The PHENOSAR trial: Antibiotic treatment of biopsy confirmed phenotypes in sarcoidosis: a proof of concept clinical trial

This study has been transitioned to CTIS with ID 2024-513534-38-00 check the CTIS register for the current data. Investigate whether treatment with azithromycin has an inhibitory effect on the mTOR pathway and/or C. acnes, causing a reduction of the…

Development of a *two hit* in vivo autologous platelet transfusion model in healthy volunteers

To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers

Driving pressure during general anesthesia for open abdominal surgery - a randomized controlled trial

The overall objective of this RCT is to determine the effectiveness and long-term outcome of an high PEEP strategy, aiming at preventing atelectasis, but avoiding an increase in driving pressure, during intraoperative ventilation. Specifically, this…

A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Idiopathic Pulmonary Fibrosis (IPF)

The aim of this study is to evaluate the efficacy, safety and tolerability of BI 1015550 9 mg BID and 18 mg BID compared to placebo in patients with IPF, in addition to the patient's standard of care. The primary objective of this study is to…

A Randomized, Sham Controlled, Double-blinded, Multi-center Trial to Evaluate the Efficacy of the VentFree Respiratory Muscle Stimulator to Assist Ventilator Weaning in Critically Ill Patients

The primary objective of the trial is to determine whether abdominal FES reduces the duration of invasive mechanical ventilation in critically ill adult patients compared to a sham control.The secondary objectives are to determine whether abdominal…