97 results
The purpose of this study is to determine whether early intervention with subcutaneous (s.c.) secukinumab 300 mg in patients with new-onset moderate to severe psoriasis may lead to prolonged symptom-free periods by preventing reactivation of old…
Firstly, to study the reduction in sick-leave time achieved by the treatment protocol. Secondly to study the quality of life in the patients treated in the fast-track protocol, to study the reduction in societal costs and to stdy the efficacy of a…
The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.
What is the most optimal treatment strategy for children / adolescents with knee complaints? Our hypothesis is (based on the invasive surgical procedure) patients that will be surgical treated (index group) have a clinical relevant gain of pain…
Primary Objective To compare tacrolimus dosing of the new Envarsus®-based immunosuppressive regimen with current clinical practice over 6 months following de novo renal transplantation in a real-life setting in different European Countries.…
To demonstrate non-inferiority of Toujeo versus *standard of care* basal insulin therapy asmeasured by HbA1c change from baseline to Month 6.
The aim of the study is to show that a therapy based on a thrice weekly administration (i.e. at each HD session) of vitamin K1 for a period of 18 months attenuates the progression of coronary artery and thoracic aortic calcifications compared to…
To assess the safety of lengthening the adalimumab dosing interval from 2 to 3 weeks, in patients with Crohn*s disease or ulcerative colitis in long term (6 months) remission.
The aim of this post-CE study is to collect data on the effects of renal sympathetic denervation on the insulin resistance and muscle sympathetic nerve activity (MSNA) in patients with metabolic syndrome and associated hypertension.
Primary ObjectiveTo demonstrate that the effectiveness of the NOVOCART® 3D plus autologouschondrocyte transplantation system is superior to microfracture for the treatment ofarticular cartilage defects of the knee by demonstrating superiority of the…
Determining the surplus value of telehealth in addition to the standard program after a bariatric procedure
This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…
This study will investigate whether oligometastatic triple negative or BRCA1/2 related breast cancer can be treated effectively with a multimodality approach including induction chemotherapy, and whether high dose alkylating chemotherapy can improve…
The research aims to review and compare imaginairy exposure to new forms of treatment for patients with comorbid PTSD due to multiple and repeated abuse in childhood within the primary support group. It is expected that these new forms of treatment…
Primairy goal of the study is to treat anxiety disorder patients more cost-effectively (shorter treatments with equal treatment results).
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Considering the high prevalence of smoking and tobacco related deaths, knowledge about the appealing function (attractiveness) of tobacco additives is highly significant, because they promote the initiation of smoking. This part of the investigation…
Goal is to use two non-invasive techniques (continuous cardiac output monitoring and impedance measurement) to investigate the possibility of cardiac output measurement and impedance measurement to reduce the fluid intake with 30% reduction while…
The present study will evaluate the logistics and especially the effectiveness of the proposed multi-component intervention. The results will be an important factor for decisions on the further exploitation of the RRR foundation.
Evaluation of therapeutic safety and clinical efficacy of MSC transplantation in septic shock.