429 results
If the study shows that the treatment with a sling gives an earlier return to normal function en does not give a clinically significant difference in pain experience compared to cast therapy than the traditional treatment can be adjusted. We aim at…
The hypothesis of this study is that patient barriers regarding pain management can be diminished by individual nurse-led education (the Pain Education Program), resulting in lower pain intensity and better quality of life of patients.
To determine the best treatment for anaplastich oligodendroglial tumors with combined 1p/19q loss, and to determine the optimal treatment with respect to the maintenance of a maximal neurological and cognitive functioning.
To assess, based on a woman*s risk profile, mammographic density and age, the most cost-effective screening method, mammography or MRI, for women at high risk.
Optimization of safety of risk stratification for outpatient treatment in pulmonary embolism, through randomization between Hestia approach with or without NT-proBNP measurement.
We like to demonstrate that treatment of non-muscle invasive bladder carcinoma with incomplete TUR and IL-2 is therapeutically more effective than treatment with complete TUR and IL-2.
The goal of this study is to determine whether radiosensitization with carboplatin or the addition of Isotretinoin to maintenance therapy improves cure rates for children with other than average risk medulloblastoma/PNET.
The objective of the study is to diminish the amount of chemotherapy and/ or radiotherapy for children with Hodgkin lymphoma who are likely to receive too much treatment with current treatment protocols.
To evaluate the effectiveness and safety of concentration controlled combination of once daily dosed low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels:3-5 ng/ml), in order to provide superior renal function…
To explore if the addition of bevacizumab to temozolomide improves outcome as compared to treatment with temozolomide alone in patients with recurrent low grade and anaplastic glioma without combined 1p/19q co-deletion after prior radiotherapy and…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
The purpose of GRN-study is: 1. to determine the long-term effectiveness of a 12 weeks lasting physical exercise training program. 2. to determine the costeffectiveness of the 12 weeks lasting physical exercise training program. In aim of the GRN-…
Marsupialization and placement of a word catheter for the management of the cyst or abscess of the bartholin gland will be studied. Medical effectiveness in terms of recurrence of the cyst or abscess after 1 year follow up will be evaluated. Patient…
Evaluating the current dosing guidelines in children taking the half-strength paediatric tablets will provide reassurance that the recommended lopinavir/ritonavir dose provides adequate drug exposure and maintains efficacy.This trial will evaluate…
The hypothesis of the FAME II trial is that FFR-guided PCI (with DES) plus optimal medical treatment is superior to optimal medical treatment alone. The overall purpose of the FAME II study is to compare the clinical outcomes, safety and cost-…
To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…
To improve symptomatology in severe chronic failure patients.
Primary: Effectivity. Secundary: Effectivity (questionnaires, progression, surgery), safety and tolerability.
The purpose of the trial is to show that the early administration of bivalirudin improves 30 day outcomes when compared to the current standard of care in patients with STE-ACS, with an onset of symptoms of >20 minutes and <12 hours,…
The current study aims to investigate the effectiveness of a social skills training for children with ASDs in the last two grades of primary education (10-12 years old). The first objective is to investigate the effectiveness as compared to no…