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Women*s Hormonal Intervention Study in early Postmenopause of Estradiol-progesterone Replacement therapy - effects on quality of life

The primary objective is to evaluate health related QoL under an oral sequential treatment with natural steroid hormones: Duogestan®. The secondary objective is to evaluate the bleeding patterns over a one-year period.

Drug eluting BALLoon angioplasty to prime bifuRcation lesiOns for stenting: a prOspective randoMized trial

The study will assess the hypothesis that for treating a bifurcation lesion in a coronary artery the combination of a drug eluting balloon and a bare metal stent is non inferior to the standard provisional T-stenting technique using a drug eluting…

Use of guided imagery in patients with fibromyalgia: effects on pain, self agency and physical functioning

The main objective is to gain insight into the effects of guided imagery on pain, self efficacy and functional status of people with fibromyalgia and into the relationships between these outcome variables.

Reduction of antibiotic use in the ICU:
Procalcitonin guided versus conventional antibiotic therapy in patients with sepsis in the ICU

Is the duration of Procalcitonin guided antibiotic therapy shorter than standard antibiotic therapy in patients with sepsis admitted to the ICU and treated with antibiotics

A 24-month, Prospective, Randomized, Active-Controlled, Open-Label, Rater Blinded, Multicenter, International Study of the Prevention of Relapse Comparing Long-Acting Injectable Paliperidone Palmitate to Treatment as Usual with Oral Antipsychotics Monotherapy in Adults With Schizophrenia.

Primary ObjectivesThe primary objective is to assess the efficacy (primarily through time to relapse) of long-acting injectable (LAI) paliperidone palmitate compared to treatment as usual with orally administered antipsychotics in monotherapy over…

Effects of transcranial direct current stimulation
on cortical asymmetry and behaviour

To evaluate the effects of tDCS on modulating and stydying frontal brain asymmetry.

Stimulation Of Preventing Post Operative Nausea and Vomiting

Testing nerve stimulation as a preventive measure to reduce the incidence of PONV.

Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected early-onset neonatal sepsis: multicenter prospective randomized intervention study

1. To decrease the proportion of infants treated with antibiotics for > 48 - 72 hours with possible or unlikely infection. 2. To reduce the duration of antibiotic therapy

Caregiving fathers: do hormones help them along?

This proposal centers on hormone-behavior dynamics in paternal caregiving, with the goal of gaining a better understanding of the development of human paternal caregiving. There is limited information on the hormonal basis of caregiving patterns in…

The persisting effect of episodic exercise training in patients with chronic heart failure.

Determine the prolonged effect of a 12 week physical exercise program in congestive heart failure patients.

Child maltreatment reports to Dutch child protection agencies with the maltreated child as an active informant: insights in the mental health and quality of life of the maltreated child and care consumption: a prospective study and an RCT

The general objective of this study is to contribute to the knowledge on the approach of the Dutch CPA*s. More specific objectives of this research are: 1. To determine the course of the mental health and quality of life of abused children from 5 to…

Pilot Study of BB3 to Improve Renal Function in Patients with Signs and Symptoms of Significant Renal Injury after Kidney Transplantation from Donors after Cardiac Death.

To evaluate the safety and activity of BB3 compared to placebo in improving renal function in the immediate post-transplant period in patients who have received a DCD kidney transplantation.

Do washed irradiated red blood cells with a balanced solution improve the quality of the priming in cardiopulmonary bypass for neonates and infants?

Improve the quality of red blood cells used for cardiopulmonary bypass for neonates and infants with a bodyweight smaller then 10 Kg.

Study of Myocardial Recovery after Exercise Training in Heart Failure

The extent of beneficial effects of AIT, including reverse remodeling and improved left ventricular function, exercise capacity, quality of life and level of physical activity, needs to be established in a phase II type clinical multicenter study…

Evaluation of a standardized cognitive behavioural therapy programme of depression after traumatic brain inury or stroke.

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A Multi-center, Randomized, Double-blind, Placebo-controlled Study of AMG 785 in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture Status Post Definitive Fracture Fixation with an Intramedullary Nail.

To investigate the effect of AMG 785 compared to placebo on time to radiographic healing of fresh tibial diaphyseal fractures.

Decreasing acute peripheral neuropathy in patients treated with Oxaliplatin
(heated oxaliplatin versus oxaliplatin on room temperature)

Objective: Main object Does warming of oxaliplatin, during the two hours infusion period, reduces the acute peripheral neuropathy complaints of patients with a colo-rectal tumor more than 50% in comparison with the standard treatment?Secondary…