20 results
The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…
Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…
The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…
PrimaryThe 3 months* effect of Vildagliptin on insulin synthesis and storage capacitySecondaryThe 3 months* effect of vildagliptin on- Glucose, insulin, C-peptide levels- Hormonal axes, most importantly GLP1 and GIP and Glucagon- Body weight, body…
The main objective is to investigate whether and at what dose vitamin K2 increases carboxylation of MGP. Secondary objective is to investigate the effect of vitamin K2 on markers of CVD (osteocalcin, blood lipids, inflammatory factors and insulin…
Assess whether APL180 can improve endothelial function in patients with Familial hypercholesterolemia
· To determine therapeutic efficacy of Tracleer in patients with active Behcet disease. Furthermore:· To study cytokine and immunological patterns and ET-1levels in those patients.
1. The objective of this pilot study is to investigate if 72 hours 30% calorie restriction + 24 hours of pre-operative fasting has a beneficial effect on post-operative recovery. 2. The perioperative cytokine response in fasting and non-fasting…
The main aim of this study is to assess hypothesis A, and we will perform an exploratory analysis on hypothesis B.
The primary objective is to determine if MK-7 supplementation leads to stabilization or attenuation of ongoing calcium deposition, quantified by 18F- NaF PET/CT imaging in patients with type 2 diabetes.
Objectives: To investigate the effect of a daily sachet of probiotics on vitamin K status for 12 weeks vs placebo.
The primary objective of the study is to test the effectiveness of bumetanide across the whole spectrum of sensory processing disorders within ASD, ADHD and/or epilepsy. We also want to determine which subgroups (high/low IQ, comorbidities or not)…
To study the efficacy and safety of FMT augmented by donor selection and repetitive dual route administration.To study microbiota composition, functional and metabolic changes as a result of dietary modulation and FMT.
To investigate whether fecal microbial transplantation (FMT) from either allogenic (individuals with type 1 diabetes and a highly preserved beta cell fraction) or autologous (own) donor, administered every 8 weeks during 6 months through a small…
In this study we would like to investigate whether fecal transplantation, administered through a nasoduodenal tube, from either allogenic or autologous donors, has beneficial efffects on IBS symptoms such as abdominal pain intensity and frequency,…
To study the impact of AKCEA-APOCIII-LRx on lipid and inflammatory measurements in the fasting and postprandial phase.
To investigate the effect of probiotics for 12 weeks on vitamin K status vs placebo.
This proof of concept study is to estimate the effect of SRCaBu (600 mg daily for four weeks) on compositional and functional characteristics of the microbiome for future sample size calculation.The secondary objectives: 1) To evaluate the short-…
In this study we will investigate whether changes in gutmicrobiota composition induced by fecal transplantation from *preserved* type 1 diabetes mellitus, administered through a small intestinal tube, has beneficial effects on residual beta cell…
This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…