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Randomized placebo-controlled pilot study to determine the effect of probiotics on vitamin K status in renal transplant recipients

To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.

Mobile screening for major depressive disorder in adults from an ethnically and socioeconomically diverse population.

2. OBJECTIVESThe overarching goal of this proposal is to examine the feasibility and effectiveness of mobile-based screening for MDD. We combine validated screening and interventions for MDD with innovative outreach methods to maximize impact.…

Spinal Muscular Atrophy Randomized Controlled Trial on Cough Techniques
(Patient tailored airway clearance in patients with Spinal Muscular Atrophy: a randomized controlled trial comparing air stacking and mechanical insufflation-exsufflation.)

The aim of this study is to compare the effect of twice daily MI-E to twice daily AS with MAC on increase of PECF in patients with SMA with weak cough over a period of 3 years.

Effectiveness of a guided e-health CBT-I based intervention for insomnia in autistic adults (i-Sleep Autism)

Objective: To test if participants with autism engaging in a CBT-I based online guided intervention (i-Sleep Autism) will experience a significant reduction in insomnia symptoms and improved mental health outcomes compared to the control group (…

A randomized clinical trial to study positive effects of "T-REX Twente regimen" (Thoracic surgery Rehabilitation Experts Twente) on quality of life and mobilisation activities for cardiac surgery patients after full median sternotomy, compared to usual care

Do the T-REX Twente precautions have a positive impact on the quality of life (MAcNew QLMI), level of physical activity, and reduction of fear of movement in heart patients after a total median sternotomy compared to the (current) standard…

Treating Suicidality Remotely: a randomized controlled trial of brief cognitive behavioral therapy for suicide prevention via chat or phone

Therefore, the main purpose of this study is to investigate whether this online intervention can indeed help prevent suicide attempts. In addition, we want to examine whether the intervention affects thoughts of suicide, quality of life and broader…

MASTER: A study on the effects of a parent training for toddlers with emotion dysregulation and an increased likelihood of developing ADHD

Primary intervention objective: to evaluate change in emotion dysregulation in at-risk-for-ADHD toddlers (24-36 months) during the 8-week intervention period of MASTER compared to the 6-week baseline (control) period. Secondary intervention…

Preventing and Reducing Child Sexual Abuse Material (CSAM) use through On-device Technology (PROTECH)

The first objective is to test whether the tool is promising for individuals to support them in managing their problematic use of CSAM. The second objective is to develop a blueprint to maximize the reach and impact of safety technology for…

Biomarker-Guided Intervention to Prevent Acute Kidney Injury after Major Surgery; The Prospective Multicenter Randomized Controlled Interventional Trial

The primary objective of this study is to investigate the effect of the implementation of the KDIGO bundle in patients at high risk for AKI after major surgery as compared to standard of care.

A randomized control trial to assess if changing sleep timing can improve glucose metabolism in people with (pre)diabetes

To investigate whether a reduction in social jetlag for 3 weeks can improve glycemic and metabolic control, sleep, mood and quality of life in people with (pre)diabetes.

Randomized controlled trial of controlled hand/foot cooling to prevent neuropathy and preserve quality of life in adults treated with oxaliplatin.

This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.

Perioperative Lipofilling in Operative Treatment of Proximal Phalanx Fractures and Related Tenolysis: Improving Range of Motion

The aim of the two separate studies is as follows: 1. To evaluate the effect of perioperative micronised lipofilling in patients with ORIF of P1 fractures on postoperative range of motion2. To evaluate the effect of perioperative micronised…

PREBICC: Prebiotic intervention in patients with advanced colorectal cancer treated with 5-FU based chemotherapy: a randomized controlled clinical intervention study

This intervention study aims to investigate the effects of daily administration of a prebiotic fiber mixture in a Nutritionally Complete Oral Nutritional Supplement (ONS) for 8-9 weeks on intestinal microbiota composition and diversity in patients…

FeelGood: Increasing perioperative positive emotions by Cognitive Bias Modification

To study the efficacy of preoperative CBM in patients with increased anxiety levels undergoing knee- or spine surgery with expected postoperative moderate to severe pain.

Gownless Hand Surgery Trial

: To investigate whether the omission of surgical gowns during CTR and TVR surgeries af-fects postoperative wound infections

Interpersonal Therapy for Refugee Parents in Community Settings

The aim of this research project is to assess the feasibility and acceptability of an adapted version of Group Interpersonal Therapy [IPT] for parents from refugee backgrounds in primary care in The Netherlands. Moreover, the potential effectiveness…

Prevention of diabetes with a novel butyrate-enriched triglyceride

Primary Objective:The main goal of the study is to investigate the effects of a chronic increase in the gut microbial metabolite butyrate and hexanoate in the systemic circulation on peripheral insulin sensitivity in individuals with overweight/…

The effect of a single session of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on whole-body protein turnover in sedated intensive care unit (ICU) patients

To examine the effect of a single session of whole-body NMES, with or without subsequent protein intake, on whole-body protein turnover

PROFID EHRA
PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator im-
plantation

To demonstrate that in post-MI patients with symptomatic heart failure who receive optimal medical therapy (OMT) for this condition, and with reduced LVEF <=35%, OMT without implantable cardioverter defibrillator (ICD) implantation (index…

A web based cognitive behavioral therapy that addresses gender
dysphoria, gender minority stress and suicidality among gender minority youth. A Randomized Control Trial

Research question:To what extent is a web-based, Cognitive Behavioral Therapy (CBT) specially designed for young gender diverse youth in the Netherlands, an effective treatment to reduce their suicidality? Are there gender, sex assigned at birth,…