82 results
Primary Objective: To determine the effectiveness of a comprehensive lifestyle intervention program aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.Secondary Objective:…
1. To reduce the time required for pre-exposure rabies vaccination of military personnel2. To reduce costs of pre-exposure rabies vaccination of military personnel 3. To obtain a non-inferior immune response to a shortened, low-dosed scheme compared…
Primary ObjectiveThe primary objective for this study is to compare the clinical efficacy of weekly abatacept in combination with methotrexate to methotrexate alone in achieving Remission, defined as SDAI less than or equal to 3, at Week 24.…
Main objective:To assess the efficacy of thromboprophylaxis with high prophylactic dose LMWH as compared with standard care without systemic thromboprophylaxis in children treated for primary ALL during asparaginase treatment.Secondary objectives:1…
Primary Objective To compare tacrolimus dosing of the new Envarsus®-based immunosuppressive regimen with current clinical practice over 6 months following de novo renal transplantation in a real-life setting in different European Countries.…
We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…
1. To determine the efficacy of QPI-1002 to reduce the incidence and severity of delayed graft function in comparison to placebo in recipients of a donation after brain death (DBD) older donor kidney.2. To assess the safety and tolerability of QPI-…
To evaluate the safety, tolerability and immunogenicity of a Twincer®-administered dry powder influenza vaccine in healthy adults.
Primairy Objective* To test whether 5-ASA reduces the occurrence of colonic benign or malignant neoplasia compared to placebo in Lynch syndrome (LS) patients as detected by any colonoscopy until the end of study.Secondary Objectives* To test wheter…
treatment of overweight persons with insulinresistance with a low dose metformine add to yoghurt The early reduce of glucose especially the postprandial will hopefully decrease this process. This reduce of the glucose only needs to be 1 mmol and we…
There are indications that early laser treatment of wounds can reduce scar formation. With the laser device the wound will be heated, which is thought to be responsible for a reduced inflammatory reaction and hence for a reduced scar formation. The…
To determine whether aleglitazar reduces cardiovasculair mortality and morbidity (defined as non-fatal myocardial infarction (MI) and non-fatal stroke) in patients with a recent ACS event and type 2 diabetes.
The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…
The objective of the study is to investigate the effects of bright light combined with physical activity during the morning on subjective and objective outcomes related to sleep-wake cycle and the rest-activity rhythm in persons with MCI, aged 65…
Considering the high prevalence of smoking and tobacco related deaths, knowledge about the appealing function (attractiveness) of tobacco additives is highly significant, because they promote the initiation of smoking. This part of the investigation…
To evaluate whether preventive treament with haloperidol lowers the risk for delirium in stroke patients with an increased risk for delirium.
To determine a suitable co-trimoxazole regimen for testing in a future larger clinical trial to determine the efficacy of antibiotic prophylaxis in patients with a temporary urinary tract catheter.
Goal is to use two non-invasive techniques (continuous cardiac output monitoring and impedance measurement) to investigate the possibility of cardiac output measurement and impedance measurement to reduce the fluid intake with 30% reduction while…
The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.
Effect of folic acid supplementation in pregnancy on preeclampsia - Folic Acid Clinical
Trial (FACT)
Primary ObjectiveThe overall aim is to evaluate a new preeclampsia (PE) prevention strategy: 4.0mg (1.0mg x 4) of folic acid supplementation vs. placebo from early (80/7 to 166/7 weeks of gestation) pregnancy until delivery.Secondary ObjectivesTo…