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Fecal calprotectin guided referral strategy in children in primary care

Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.

Visability during arthroscopic shoulder surgery: influence of epinephrine

To determine whether the use of epinephrine saline irrigation in therapeutic shoulder arthroscopy with need for subacromial procedures should significantly increase clarity of the view.

HF Outpatient Monitoring Evaluation (HOME) Study

To determine if HF subjects whose treatment is assisted by a daily BNP measurement that is integrated into a home health management system will have improved clinical outcomes versus subjects whose treatment includes home health management but is…

Gel instillation sonohysterography (GIS) using Endosgel versus ExEmgel, comparison of pain and image quality

The objectives of this trial are:- To compare experienced pain during GIS using ExEmgel versus Endosgel (continuous measure pain and subjective reported VAS score)- To compare the image quality, including the occurrence of air bubbles during both…

Posture or Patching (PoP). Accelerated clearing of the media with massive vitreous hemorrhage and suspected retinal tear.

Objective: To investigate whether binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants or not.

Dientamoeba fragilis: clinical symptoms, optimal treatment and molecular detection

1. To determine clinical symptoms of Dientamoeba fragilis infection. 2. To evaluate the efficacy and safety of clioquinol versus metronidazol in the treatment of Dientamoeba fragilis in children.3. To evaluate the duration of positive PCR…

Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected early-onset neonatal sepsis: multicenter prospective randomized intervention study

1. To decrease the proportion of infants treated with antibiotics for > 48 - 72 hours with possible or unlikely infection, with unchanged outcome. 2. To reduce the duration of antibiotic therapy

Better Evaluation of Acute Chest Pain With Computed Tomography * a Randomized Prospective Trial

To compare the diagnostic value of CTA versus the standard work-up in terms of identifying patients with severe coronary artery disease (requiring revascularization), as well as the ability to safely discharge patients without coronary artery…

Systemic therapy with or without Up front surgery of the primary tumor in Breast cancer patients with distant Metastases at Initial presenTation (SUBMIT, BOOG 2010-05)

Up front breast surgery in patients with primary distant metastatic breast cancer, will result in an improvement of the 2-year survival compared to the survival achieved with systemic therapy and delayed local treatment or systemic therapy alone.The…

The influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of aspiration pneumonia in physically-impaired care home residents with dysphagia.

Primary objective: To assess the influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of pneumonia in physically-impaired care home residents with dysphagia.Secondary…

Colonoscopy with EndoCuff vs conventional colonoscopy
A randomized controlled trial

We aim to test the hypothesis that EndoCuff improves totaal number of adenomas detected and ADR compared with regular colonoscopy. In other words, we'll study if the Endocuff colonoscopy detects more polyps.

Randomized trial of Legflow® Paclitaxel eluting balloon (LPEB) with stentplacement vs. standard PTA with stentplacement for the treatment of intermediate (>5 cm and < 15 cm) and long (>15 cm) lesions of the superficial femoral artery (SFA). The RAPID trial.

The primary objective is to assess the difference in absence of binary restenosis rate of endovascular treatment of intermediate and long lesions of the superficial femoral artery with the Legflow® PEB and nitinol stent, when compared to uncoated…

The sword of Damocles. Managing fear of cancer recurrence with the SWORD intervention study (Survivors' Worries of Recurrent Disease).

Cognitive behavior therapy (CBT) seems a promising intervention to reduce FCR. The SWORD study (Survivors* Worries of Recurrent Disease) will examine the efficacy and cost-effectiveness of individual CBT compared to treatment as usual (TAU) in…

Early pharmacological intervention to prevent delirium: HAlopeRidol PrOphylaxis in Older emergency department patieNts.
The HARPOON study

Primary objective(s):To evaluate the effect of early haloperidol prophylaxis on the incidence, severity and duration of in-hospital delirium in at-risk patients aged 70 years and over who are acutely admitted to the hospital through the ED, for…

Randomised comparison of endoscopic trimodal imaging versus chromoendoscopy as surveillance strategy for neoplasia in ulcerative colitis

Comparing differentiation and detection of neoplasia in patients with ulcerative colitis undergoing surveillance, by ETMI and CE, in a randomised trial.

A randomised phase III trial comparing a strategy based on molecular analysis to the empiric strategy in patients with carcinoma of an unknown primary;A la carte CUP treatment using the CancerTYPE ID test

Determine wether or not a strategy based on molecular analysis is effective in improving the PFS

THL study: A multicenter trial comparing the cost-effectiveness of transvaginal hydrolaparoscopy and hysterosalpingography in the work-up for subfertility.

Objectives: The purpose of this study is to assess the costs and effects of THL compared to HSG in a large randomized controlled trial.

SIGnificance of routine Hysteroscopy prior to a first 'in vitro fertilization' (IVF) Treatment cycle

The aim of the proposed study is to assess whether diagnosing and treating unsuspected intrauterine abnormalities by saline infusion sonography and/or routine office hysteroscopy prior to a first IVF/ICSI treatment cycle improves the cost-…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients.
The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study.

OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.