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Uniform FDG-PET guided gradient dose prescription to reduce late radiation toxicity (UPGRADE RT): a randomised controlled trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…

RCT to investigate the quality of the of endometrial sample obtained by aspiration when performed before or after the SIS in postmenopausal women.

The primary objective is to investigate the quality (whether assessable by a pathologist or not) of the endometrial sample obtained by aspiration when performed directly before or after the SIS in postmenopausal women. Secondary objectives are to…

Effectiveness of ultrasound imaging in general practice: optimising the management of patients with non-chronic shoulder complaints.

To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…

A randomized, open label, multicenter Phase 2/3 study to evaluate the efficacy and safety of rogaratinib (BAY 1163877) compared to chemotherapy in patients with FGFR-positive locally advanced or metastatic urothelial carcinoma who have received prior platinum-containing chemotherapy

The primary objective of the entire study is to compare rogaratinib (BAY1163877) with chemotherapy (docetaxel, paclitaxel or vinflunine) in terms of prolonging the Overall survival (OS) of patients with FGFR positive urothelial carcinoma.

A Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders.

Primary Objective: To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.Secondary Objectives:1. To compare the efficacy of MEDI-551 versus placebo on the reduction of EDSS…

Immunisation, Treatment and Controlled Human Hookworm Infection

Primary objective:* To determine the protective efficacy of repeated short term exposure to hookworm infection Secondary objectives:1. To explore the immunological response after repeated hookworm infections2. To evaluate the safety of and number of…

Hemodynamic Monitoring with the CardioMEMS PA sensor and Quality of Life in Patients with Chronic Heart Failure: The MONITOR HF Trial

We hypothesize that the CardioMEMS HF system will be safe and superior to standard care in improving the quality of life and health status in patients with chronic HF in the Netherlands. Additionally, we hypothesize the CardioMEMS HF system is cost-…

TANGO-DM: Randomized trial of effective treatment according to new GDM criteria

To evaluate the effectiveness and cost-effectiveness of intensive GDM treatment as compared to routine maternity care in pregnant women with a discordant OGTT result between the new (2013) WHO criteria as compared to the old (1999) WHO criteria for…

Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and asperin, versus IVIG and asperin for prevention of coronary artery aneurysm (CAA) in Kawasaki disease (KD)

The overarching goal is to optimise the treatment of KD in children/adolescents across Europe.KD-CAAP will test the hypothesis that adding immediate adjunctive corticosteroid treatment to IVIGand aspirin will reduce CAA rates in unselected KD…

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

• Evaluate the safety of ME-APDS in subjects during colonoscopy.• Assess the efficacy of ME-APDS - whether the use of the ME-APDS improves the Adenoma Per Colonoscopy APC when compared to conventional colonoscopy (CC). Thereby we aim to further…

The effect of intradialytic parenteral nutrition on nutritional status and quality of life in hemodialysis patients

The aim is to see whether intradialytic parenteral nutrition is an efective treatment against the loss of muscle mass

High-dose alkylating chemotherapy in oligo-metastatic breast cancer harboring homologous recombination deficiency

This study will investigates the effect of high dose alkylating chemotherapy compared to standard dose chemotherapy as part of a multimodality approach in patients with oligometastatic HRD positive and/or BRCA1/2 related breast cancer.

Stress reduction in formerly preeclamptic women; sofa or sports?

To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…

Efficacy of Diltiazem to improve coronary microvascular dysfunction: A randomized clinical trial

This study has been transitioned to CTIS with ID 2024-512030-15-00 check the CTIS register for the current data. Our primary objective is to assess the effect of diltiazem on coronary microvascular function as assessed by coronary reactivity testing…

Innovative diagnostics and treatment of misophonia in children and adolescents: a new psychiatric disorder

The two objectives of this study are: 1) validation of two questionnaires, the Misophonia Screening List - Child and Youth and the Amsterdam Misophonia Scale-Youth (AMISOS-Y) in order to screen adequately for misophonia2) testing the effectiveness…

EuroNet-Paediatric Hodgkin*s Lymphoma Group ;Second International Inter-Group Study
for Classical Hodgkin*s Lymphoma in Children and Adolescents

The aim of this study is to reduce the indication for RT without compromising cure rates. To investigate if intensified consolidation therapy (DECOPDAC-21) compared to standard consolidation therapy (COPDAC-28) can compensate for reduction in RT.

Mechanism of Action and Clinical Effect of BI 655130 in Patients with fistulizing Crohn*s Disease

The primary objectives of this trial are:- To explore the pathomechanisms involved in the generation and healing of CD associated perianal fistulas- To understand the MoA of BI 655130 in patients with CD and draining perianal fistulas

Withdrawing off-label antipsychotics in people with intellectual disabilities: why does it fail?

The study is designed to investigate why withdrawal of off-label antipsychotic drugs for behavioral problems in people with intellectual disability often fails by comparing two blinded groups (withdrawa group versus control group). This has led to…