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Screening and treatment of psychological distress in colorectal cancer with metastasized disease: the TES-trial

We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…

eVita COPD; Patient Centered Care through eHealth Solutions

The main aim is to investigate clinical effects of different implementation methods of online supported self-management for COPD patients in primary care. Secondary objectives include effects on well-being, health care use and actual use of the…

Erasmus MC Care Innovation for a healthy pregnancy. Efficacy of "Smarter Pregnant", an interactive food and lifestyle program on the mobile phone.

Investigate whether the "Smarter Pregnant" intervention in comparison with four screenings with food- and lifestyle advising leads to an improvement in unhealthy food habits (vegetables, fruit, folic acid use) after 24 weeks intervention,…

Neurogenic bladder in children: use of feed-back tools during standard treatment with anticholinergics.

We aim to increase patient compliance by extending the existing treatment protocol of (oral or intravesical) anticholinergics plus application of CIC with the addition of bladder pressure measurement performed at home during CIC plus access to an…

Cluster randomized controlled intervention trial on the effects of Cognitieve Adaptation Training (CAT) as a nursing intervention on the functioning of long-term hospitalized patients with severe mental illness.

The primary goal of the study is to evaluate the effect of CAT on daily functioning and community participation, and thereby psychosocial well-being. Secundairy goals are evaluating the implementation of CAT in the usual care and eveluation of the (…

Effectiveness of an interactive web-based platform and a disease specific information website in patients with heart failure: a 3-arm randomised trial.

- To assess whether a disease specific educational website improves self-care behaviour and quality of life of patients with HF as compared to usual care.- To assess whether a disease-specific educational website plus an interactive web-based…

Effect of Acupuncture on sedation requirement during Colonoscopy
(EAcCo)

We hypothesize that acupuncture reduces the dosage of sedatives for colonoscopies. We will compare three groups to test our hypothesis. One group will receive verum-acupuncture, another group sham-acupuncture and the third group will be the control…

TELEHYPE TELEmonitoring and self-management of uncontrolled HYPErtension

To assess the one-year (cost)effectiveness of telemonitoring of blood pressure and self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with uncontrolled…

A randomised, double-blind, placebo-controlled trial for establishing safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of multiple subcutaneous doses of BI 655064 in healthy volunteers and in rheumatoid arthritis patients with prior inadequate response to methotrexate therapy

This study has two parts. The main purpose of Part 2 of this study is to see how safe and effective different doses of BI 655064 are as well as to look at the pharmacokinetics (the amount of medication in your blood) and the pharmacodynamics (the…

Implementation of a Transcutaneous Bilirubinometer among Newborns: A Randomized Controlled Trial

To optimize the quality and cost-effectiveness of care for jaundiced neonates in the Isala Klinieken.

Supporting primary care in diagnosis and choice of treatment for patients with psychosocial symptoms: SGE-PsyScan.

Improving primary care for patients with psychosocial symptoms by introducing the SGE-PsyScan.

Pilotonderzoek naar de effectiviteit van een web-based computerhulp ter ondersteuning van gezamenlijke besluitvorming tussen patiënt en behandelaar in evaluatie van Routine Outcome Monitoring (ROM)

The primary objective of this study is to examine whether web-based Wegweis tool can support processes of shared decision making in ROM evaluation and treatment planning regarding people with psychotic disorders.

Effectiveness and efficiency on quality of life of an awarenessprogram on sensory processing Issues for adolescents and adults with autism spectrum disorders and a normal or high IQ.

The objective of this study is evaluation of an awarenessprogram on sensory processing Issues on effectiveness and efficiency with regard to quality of life.The central researchquestion is: what are the effects on experienced quality of life of the…

Effects of a multifaceted *teleguided* pain care programs in patients with cancer

The aim of this study is to evaluate the effect of the intervention regarding pain intensity and quality of life as compared to care as usual. Secondary outcomes of the effect evaluation are self-efficacy, knowledge, depression and anxiety, and…

Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome and a high bleeding risk: optimization of antiplatelet treatment in high-risk elderly

To assess the safety, efficacy and net clinical benefit of clopidogrel versus the new antiplatelet drugs i.e. ticagrelor and prasugrel in patients older than 70 years.

Scrutinizing (in)efficient use of cholecystectomy: a randomized trial concerning variation in practice.

Current practice variation in selection of patients with gallbladder stones and abdominal complaints for cholecystectomy is not efficient. Here we evaluate stepwise selection for surgery to improve patient outcome and to reduce the number of…