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Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

A prospective Randomized Single Blinded Clinical Study on TKA
with and without Orthosensor

The current study evaluates the OrthoSensor and investigates whether the combination of the Vanguard® Knee System with the OrthoSensor results in a faster recovery and better clinical outcomes during short follow up compared to conventional TKA (…

Effects of timing of hypercaloric snacking diets on metabolism and brain

To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.

Sensitive skin and skin irritation. Characteristics and diagnostic tools.

Objective: The primary objective is to investigate whether sensitive skin fundamentally differs from *normal skin*. In this study, we try to identify the morphological and functional characteristics of sensitive skin by provocation of the skin with…

Facilitation of human long-term memory with post-learning physical exercise

To examine the behavioural and neural effects of a single session of post-learning exercise on long-term memory retention in humans.

The influence of Deep Brain Stimulation on the critical elements of cognitive control in Obsessive-Compulsive Disorder Patients.

In the proposed study, we will experimentally elucidate the effect of DBS on various critical dimensions of cognitive control including: the free will experience, instrumental learning, environmental change detection and working memory.

Enteral versus parenteral feeding in adult stem cell transplantation patients with chemotherapy-induced gastro-intestinal mucositis.

In this study, we will test which of two feeding strategies for adults during chemotherapy-induced mucositis is optimal with regards to maintaining an optimal body weight, nutritional status, gut mucosal barrier and treatment outcome (including…

Butyrate Use in TYpe 1 diabetes: effects on Regulation of bActerial translocation, innate immunity, T-cell function and Endotoxemia

To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.

The effects of galactooligosaccharide (GOS) on peripheral insulin sensitivity and body weight control in obese adults with impaired glucose homeostasis

Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…

Fear conditioning during specific conditions in antisocial adolescents: a neuroimaging study.

The primary objective is to investigate brain functioning during (reversal) fear conditioning and reward/punishment conditions during different experimental conditions. Secondary objectives include investigation of connectivity between brain…

Rosuvastatin use to improve the coagulation profile in patients with venous thrombosis: The STAtins Reduce Thrombophilia (START) Study

To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.

A 3-month Multicenter randomized trial to evaluate the efficacy of a Physical Activity Promotion Program on the experience of physical activity in patients with COPD (Mr PAPP)

The purpose of this study is to test the impact of a physical activity promotion program which is a personalized, semi-automated, coaching program utilizing an smartphone on which an app is installed and coaching by the investigator. The automated…

Does a decision aid improve decision making in prosthetic heart valve selection?

Conduct a multicenter randomized clinical trial to assess whether the use of the decision aid results in optimization of shared-decision making and improved quality of life in patients who have been accepted for aortic and/or mitral valve…

Decreasing social jetlag with blue light blocking (reducing) glasses

To elucidate the changes in the timing of sleep and waking, sleep quality and endogenous circadian phase in different chronotypes (e.g. *owls* vs. *larks*) with different amounts of social jetlag shielded from short wavelength (blue) light in the…

Effect of pre-surgical pulmonary rehabilitation on outcomes of bariatric surgery in morbidly obese patients with asthma

To determine whether pulmonary rehabilitation prior to bariatric surgery leads to improved and sustained asthma control (ACQ) as compared to bariatric surgery alone in patients with morbid obesity and not optimally controlled asthma.Secondary aims…

Effect a hypocaloric high protein diet and resistance exercise on body composition, muscle strength, physical functioning and quality of life during a weight loss trial in overweight older adults(55+).

The objective of this study is to evaluate the effects of excercise training and/or a high protein hypocaloric diet on improvement of body composition (preservation fat free mass), muscle strength, physical functioning and quality of life in an…

The role of β-adrenergic stress hormones in Eye Movement Desensitization and Reprocessing (EMDR). Part I: the effects of β-adrenergic receptor antagonist propranolol on the plasticity of emotionally arousing episodic memories.

The goal of the present study is to investigate whether the blockade of NA-transmission by beta-antagonist propranolol reduces the common EMDR effects (reduced vividness/emotionality of emotional memories) in order to find out if NA-release (evoked…

The effects of attachment and emotion regulation on depression and anxiety

Aim of this study is to examine the mechanisms by which attachment style and emotion regulation relate to depressive symptoms and anxiety symptoms in a clinical and non-clinical Dutch population.

The Effect of Creatine Supplementation on Muscle Loss During Immobilisation

The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying mechanisms of creatine and disuse…

An attention bias modification training as waitlist intervention for depression:
A randomized controlled trial

Aim of the study is to evaluate the effectiveness and cost-effectiveness of a positivity training based on attention bias modification as waitlist-intervention for adult outpatients with a major depressive disorder.