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Effect of a machine learning-derived early warning system for hypotension vs standard care on depth and duration of intra- and postoperative hypotension in elective cardiac surgery - The HYPE-2 Randomized Clinical Trial

Does HPI with diagnostic guidance affect severity of hypotension (defined as MAP<65 mmHg) during both the off-pump phases of on-pump CABG surgery and the mechanically ventilated phase of post-operative ICU admission (or 8 hours maximum)?

The effects of exercise training combined with NR supplementation on metabolic health in older individuals

The primary objective of this study is to determine whether combined treatment of exercise and NR imposes greater improvements in skeletal muscle mitochondrial metabolism in older humans compared to exercise treatment alone. The secondary objective…

A preoperative program to promote peri- and postoperative health in patients undergoing thoracic aortic surgery: a randomized controlled trial.

To compare the effects of a preoperative PA program in addition to usual care versus usual care only on the change in SB from baseline (T0) to the end of the preoperative (intervention) period (T1) in patients with TAD.

Peripheral and Central Nervous System Contributions to the Subjective Experience of Emotions

The primary objective of this study is to identify the distinct roles of the peripheral and central nervous system in the subjective experience of panic.

Fecal microbiota transplantation for improved Fructose catabolism and Insulin sensiTivity In patients with metabolic syndrome : the FFIT study

We would like to investigate if use of donor FMT enriched desulfovibrio bacterial strains has a beneficial effect on gut microbiota diversity and subsequent improvement of (diet derived) fructose catabolism and insulin sensitivity in patients with…

A national randomized placebo-controlled double-blind multicenter trial of
LT4/LT3 combination therapy in patients with autoimmune
hypothyroidism.

This study has been transitioned to CTIS with ID 2024-513883-24-00 check the CTIS register for the current data. Primary Objective: To investigate the effects of LT4/LT3 combination therapy compared to LT4 monotherapy on tiredness in those patients…

Interaction between intestine and osteoarthritis of the hand and the effect of Sustained Release Calcium Butyrate

This proof of concept study is to estimate the effect of SRCaBu (600 mg daily for four weeks) on compositional and functional characteristics of the microbiome for future sample size calculation.The secondary objectives: 1) To evaluate the short-…

*Fecal Microbiota Transplantation to Preserve Residual Beta Cell Function In Patients With Newly-Diagnosed Type 1 Diabetes Mellitus: The FMT-Preserve-DM1-trial*

In this study we will investigate whether changes in gutmicrobiota composition induced by fecal transplantation from *preserved* type 1 diabetes mellitus, administered through a small intestinal tube, has beneficial effects on residual beta cell…

Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a standardized surveillance strategy - an international randomized controlled trial by the Dutch Pancreatic Cancer Group

The RADAR-PANC trial is designed to investigate whether a standardized surveillance strategy with serial tumor marker testing and routine imaging improves the overall survival in patients after radical resection for pancreatic ductal adenocarcinoma…