35 results
The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
Study I aims to explore dysregulation of biological stress systems among traumatized youths with and without ID in residential care, and compare them with a healthy control group. Study II aims to conduct a randomized controlled trial (RCT) to test…
To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.
This study has two main objectives. One objective is to investigate which cognitive and affective mechanisms can be influenced through treatment which leads to improved social functioning. We will use a carefully selected set of behavioral,…
The primary objective of our study is to determine the efficacy and safety of top-down IFX treatment in moderate-to-severe pediatric CD.Secundary objectives are determination of PK data and predictors of response to IFX in pediatric CD.
(i) To compare the DBF response to capsaicin between cystinosis patients, homozygous and heterozygous for the 57-kb deletion, and matched controls.(ii) To compare the skin sensitivity response after capsaicin application between cystinosis patients,…
The primary objective of the clinical part of EPISTOP project is to identify the clinical and molecular biomarkers of epileptogenesis in a prospective clinical study of patients with TSC. Secondary objective of the clinical part of EPISTOP is to…
are there differences in levels of IgE and sub-classes, TARC ,light chain IgG and titers against vaccins HiB and Tetanus between children who received as infant a formula with or without pre-biotics ?
This study has two main objectives. The first objective is to investigate whether children with DBD, when compared to low aggressive and antisocial control children, have neuropsychological and neurobiological abnormalities that may underlie their…
The current proposal studies the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of overweight/obese children with asthma. Also the underlying mechanism of these…
Our unique project is based on an ongoing European prenatal stress research focusing on the effect of prenatal stress on early sensory-cognitive development. We capitalize on the methodologically sound maternal and infant physiological measures…
The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…
The objective of this subexperiment is to test the hypotheses of emotional reactivity as underlying mechanism to GxE interactions in the behavior development of children. This hypotheses will be tested within an experiment in which we will look if…
The primary objective is to investigate whether a brief (10+2 sessions) Cognitive Behavioural Therapy (CBT) program can (postpone or) prevent the onset of depression or anxiety disorder in an ultra high risk sample of 8-18 year old children of…
Our objective is to test the following hypotheses : - Hypothesis 1 (part 1 of the study): The stress reduction intervention has beneficial effects on subjective maternal emotional well-being, on objective maternal stress system measures (i.e., HPA-…
1. Randomised controlled determination of the influence of foods on the behaviour of a heterogeneous not-selected group primary school children, during the first two months of the trial. 2. Determination of an IgG or IgE-mediated respons to foods,…
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
The first aim in the proposed project is to directly test the alleged role of working memory on (explicit) motor skill learning in preterm children. Our second aim is to examine the relation between implicit and explicit learning in preterms. This…
It is not known whether recurrent wheeze in preterm children is caused by RSV infection (serial hypothesis) or that RSV infection is the first indication of chronic airway morbidity that would develop anyway (parallel hypothesis). This study aims to…