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A PROSPECTIVE, MULTI-CENTRE, RANDOMISED, DOUBLE-BLIND COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE WITH MIDAZOLAM FOR CONTINUOUS SEDATION OF VENTILATED PATIENTS IN INTENSIVE CARE UNIT

Primary objective:The study has hierarchical co-primary objectives to demonstrate that:- Firstly: dexmedetomidine is at least as effective as sedation with midazolam and daily sedation stops, in maintaining a target depth of sedation in ventilated…

A randomized, double-blind phase 3 study of gemcitabine plus AG-013736 versus gemcitabine plus placebo for the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer

Primary Objective: Compare the overall survival (OS) of patients receiving gemcitabine plus AG-013736 versus gemcitabine plus placebo.Secondary Objectives: 1. Compare the progression free survival (PFS) of patients in each arm;2. Compare the…

gene-person-environment interaction in resilience against depression

My research proposal, therefore, will focus on the changeability (plasticity) of the ability to experience positive emotions in response to daily events (natural rewards), as a first step towards novel (preventive) interventions. The main question…

Effect of a lower limb strength training program on physical functioning in children with cerebral palsy

The purpose of this study is to determine the effects of a strength training program on physical functioning in children with CP.

A Phase II Study of PHA-739358 in Patients with Metastatic Hormone Refractory Prostate Cancer.

1) To assess the antitumor activity of PHA-739358 administered as IV infusion according to two different dose schedules in metastatic HRPC patients progressing on standard docetaxel-based chemotherapy.2) To have a precise idea of the antitumor…

The effect of chronic nocturnal non-invasive ventilatory support at home after ventilatory support during acute respiratory failure in patients with Chronic Obstructive Pulmonary Disease (COPD).

Does chronic nocturnal ventilatory support at home after acute respiratory failure treated by (N)IV lead to a prolongation in time to readmission to hospital due to any following exacerbations in these patients compared to medical treatment only?

A multi-center, randomized, controlled trial with programmed introduction of Sirolimus-based, Calcineurin inhibitor free immunosuppression in recipients of non-heart-beating donor kidney grafts.

To investigate the safety and efficacy of a programmed introduction of a sirolimus based calcineurin inhibitor free maintenance immunosuppressive regime three months after renal transplantation in recipients of a non-heart-beating donor kidney graft…

A randomized double-blind study of N-Acetylcysteine vs. placebo to Prevent Neurotoxicity induced by Platinum containing chemotherapy in patients treated for (Non)Small Cell Lung Cancer and Malignant Mesothelioma.

The primary objective is to establish the neuroprotective efficacy of NAC against cisplatin-induced neurotoxicity. Mainly the sensory neuronal guidance will be assessed before and after treatment with cisplatin in a group of patients receiving NAC…

Effectiveness of postoperative radiotherapy in patients with oral or oropharyngeal squamous cell carcinoma and histologically confirmed single ipsilateral lymphnode metastasis (pN1)

To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer

Differences in inflammatory and hemostatic response in cardiac surgery patients operated with conventional Cardiopulmonary Bypass (CPB) versus Minimized Extracorporeal Circulation (MECC).

The primary objective of this study is to define differences in the inflammatory response, coagulation, and fibrinolysis in CABG patients with either MECC or conventional CPB.

Memory uncertainty in OCD patients

The main objective of the study is to determine whether, and if so, to what extent, there are differences in memory vividness, detail and certainty between OCD patients, another anxiety disorder patients and healthy subjects in a repetitive checking…

On-line: Web-based Cognitive Behavioural Therapy (CBT) for Diabetic Adults with Minor to Moderately Severe Depression. A Randomised Controlled Trial.

This study aims to test the effectiveness and appreciation of a web-based cognitive behavioural therapy (CBT) program for adult diabetic persons with minor to moderately severe depression in a randomized controlled trial.

Retention of the posterior cruciate ligament versus the posterior stabilized design in total knee arthroplasty: a prospective randomized controlled clinical trial

To examine whether there is a difference in patients perceived outcome between a posterior cruciate retaining total knee arthroplasty compared with a posterior stabilized total knee arthroplasty.

The intra uterine pressure catheter, the best way to messure uterine contractions?
A comparison of the intra uterine pressure catheter and the abdominal uterine pressure measurement during labor

The objective of this study is to find out is the way contractions are maesurent during labor are of any influence on the lenght and the way women deliver. It also looks if there is any influence on neonatal outcome.

A MULTI-CENTRE,RANDOMISED,DOUBLE BLIND,PLACEBO CONTROLLED,PARALLEL GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF ONO-2506PO COMPARED TO PLACEBO,IN THE PRESENCE OF RILUZOLE,TO PATIENTS DIAGNOSED WITH AMYOTROPHIC LATERAL SCLEROSIS(ALS), WHO HAVE HAD ONSET OF MUSCLE WEAKNESS WITHIN 14 MONTHS OF RANDOMISATION

The primary objective of this trial will be to evaluate the effect of ONO-2506PO (1200 mg once daily) on the slope of respiratory function (slow vital capacity (SVC) expressed as a percentage of the predicted value) over 12 months compared with…

Treatment of panic disorder with or without agorafobia.
Mindfulness Based Stress Reduction vs. Cognitive Behavioral Therapy

The aim of this study is the comparison of Mindfulness Based Stress Reduction (MBSR), with an empirically proven effective treatment, namely Cognitive Behavioral Therapy (CBT) in the treatment of panic disorders with or without agoraphobia.

A 76-week prospective, open-label, multicenter study to evaluate the long-term effect of Exelon® capsule and transdermal patch on worsening of the underlying motor symptoms of PD in patients with mild to moderately severe dementia associated with Parkinson's disease (PDD).

The purpose of this study is to provide long-term safety data for Exelon® capsule and transdermal patch treatments, in particular the effect of Exelon® on worsening of the underlying motor symptoms of Parkinson*s Disease (PD), in patients with mild…

Mirrortherapy for improving handfunction in chronic stage after stroke: a study on its effectiveness and an fMRI evaluation of underlying cortical mechanisms.

The study objective is to evaluate, with respect to hand function, the effect of a physical therapy program based on mirror therapy compared to conventional physical therapy in chronic stroke patients and to improve our understanding of the…

Protocol CKI-301 KW-3902IV in the treatment of subjects with acute heart failure syndrome
A multicenter, randomized, double-blind, placebo-controlled study of the effects of KW-3902 injectable emulsion on heart failure signs and symptoms and renal function in subjects with acute heart failure syndrome and renal impairment who are hospitalized for volume overload and require intravenous diuretic therapy

To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…

Effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) treatment in patients with chronic tinnitus.

To study the effectiveness of low-frequency rTMS in patients with chronic tinnitus.