32 results
If the study shows that the treatment with a sling gives an earlier return to normal function en does not give a clinically significant difference in pain experience compared to cast therapy than the traditional treatment can be adjusted. We aim at…
The goal of this study is to determine whether radiosensitization with carboplatin or the addition of Isotretinoin to maintenance therapy improves cure rates for children with other than average risk medulloblastoma/PNET.
The objective of the study is to diminish the amount of chemotherapy and/ or radiotherapy for children with Hodgkin lymphoma who are likely to receive too much treatment with current treatment protocols.
Main objective: To assess the effect of Caphosol on the number of days of mucositis > grade ISecondary objective: to assess the effect of Caphosol on duration and degree of mucositis and pain, a possible influence on the occurrence of…
Evaluating the current dosing guidelines in children taking the half-strength paediatric tablets will provide reassurance that the recommended lopinavir/ritonavir dose provides adequate drug exposure and maintains efficacy.This trial will evaluate…
The current study aims to investigate the effectiveness of a social skills training for children with ASDs in the last two grades of primary education (10-12 years old). The first objective is to investigate the effectiveness as compared to no…
Main question: p. 12 of proposalIs the online psycho-educative prevention program Kopstoring a (cost) effective program for children of parents with mental or substance use disorders to reduce their symptoms (primarily reduction of internalising and…
The objective of the proposed research is to address the effectiveness of neurofeedback and exercise as non-pharmacological treatments for ADHD. The effects of neurofeedback and exercise will be assessed on three domains: behaviour, neurocognition,…
To improve physical activity levels and physical activity patterns in children with JIA by means of cognitive behavioural training based on the social cognitive theory and the health promotion model, delivered by internet and supported by group…
The purpose of the present proposal is to improve care to children with asthma by including regular assessments of non-invasive inflammatory markers during the management of asthma. In this case, treatment is also guided by inflammatory markers (…
Primary: to assess efficacy of subcutaneous 6 mg/kg GSK2402968 versus placebo administered over 48 weeks in ambulant subjects with DMD. Secondary: Safety, tolerability, PK, quality of life.
This proposed randomised controlled trial seeks to examine the effect of "GriefHelp" - a cognitive behavioural treatment for children with emotional problems following the death of a loved one. Participants are randomly assigned to two…
The main aim of this study is to determine the effectiveness and safety of nicotine replacement therapy (NRT) in achieving long-term smoking cessation among young smokers aged 12 up to and including 18 years. Other aims of this study are to…
1. Primary Objectives of the study: The primary objectives of this study are to evaluate the efficacy and safety of 2 SC dosing tiers of ustekinumab in the treatment of adolescent subjects * 12 to < 18 years of age with moderate to severe…
Primary Objective: To demonstrate the cost-effectiveness of treatment with a ketogenic diet compared to usual care in children with drug-resistant epilepsy who are not eligible for epilepsy surgery. Usual care is defined as: the child continuous to…
There are three main questions:1. How effective is internet treatment of insomnia in adolescents compared with group treatment of insomnia and control groups?2. Are the principles of cognitive behavioral therapy of insomnia in adolescents correct?3…
The aim of the CO-PRINCE study is to establish the efficacy and safety of long-term antibiotic prophylaxis with co-trimoxazolein children with recurrent upper and/or lower respiratory tract infections (including ear-nose-throat (ENT)).
1. To determine clinical symptoms of Dientamoeba fragilis infection. 2. To evaluate the efficacy and safety of clioquinol versus metronidazol in the treatment of Dientamoeba fragilis in children.3. To evaluate the duration of positive PCR…
The purpose of this study is to investigate the effectiveness of pelvic physical therapy as a SURPLUS to the paediatric usual care in children (5-17 years) with functional constipation.Other research questions are: Does pelvic physiotherapy…