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A pivotal Phase IIb/III, multicentre, randomised, open, controlled study on the efficacy and safety of autologous osteoblastic cells (PREOB®) implantation in non-infected hypotrophic non-union fractures.

To determine the efficacy and the safety of PREOB, a proprietary population of autologous bone-forming cells, in the treatment of non-infected hypotrophic non-union fractures of long bones.

ACOSOG Z4099/ RTOG 1021 A randomized phase III study of sublobular resection (+/- brachytherapy) versus stereotactic body radiation therapy in high risk patients with stage I non-small cel lung cancer (NSCLC)

This study is important in that not only will we learn information about the true oncologic differences between these therapies, we will also determine the relative impact of these therapies on pulmonary function and quality of life.

Dual sensory impairment in the older patient: a randomized controlled trial to the effectiveness of a Dual Sensory Loss-protocol

The objective of this study is to develop and test a DSL-protocol which will focus on proper use of hearing-aids, and will also provide patients (and their significant others) with specific skills to improve the use of the senses and communication.…

A randomized controlled study on the effects of time-limited cognitive behavioural therapy (CBT) for panic disorder with/without agoraphobia and social anxiety disorder with comorbidity.

Primairy goal of the study is to treat anxiety disorder patients more cost-effectively (shorter treatments with equal treatment results).

Recognition of tobacco flavours at the brain level

Considering the high prevalence of smoking and tobacco related deaths, knowledge about the appealing function (attractiveness) of tobacco additives is highly significant, because they promote the initiation of smoking. This part of the investigation…

Prospective, Randomized, Controlled, Multicentre, Open Study Releas of Paclitaxel during PTA versus PTA alone for the treatment of de-novo occluded, stenotic or reoccluded, restenotic superficial femoral (SFA) or popliteal arteries.

The study investigates the inhibition of restenosis by the Paclitaxel-eluting PTA balloon Freeway versus stenting-PTA or PTA alone in the treatment of de-novo occluded, stenotic or reoccluded, restenotic superficial femoral (SFA) or popliteal…

Navigation ability after stroke

Primary objective: To create diagnostic and treatment tools for navigation ability in stroke patients, that can be used in clinical practice.Secondary objective: To increase knowledge about the cognitive structure and neuroanatomical correlates of…

Aggression Replacement Training (ART) for aggression-regulation disorders in adults: a randomized, controlled out-patient study

The primary objective of the present study is to evaluate the effectiveness of the Aggression Replacement Training (ART) on aggression regulation disorder in a forensic psychiatric outpatient setting.A secondary objective is to examine how treatment…

Safety and Efficacy of Embozene Microspheres for Uterine Fibroid
Embolization compared to Embosphere for Symptomatic Relief from Uterine Fibroids

The purpose of this clinical trial is to compare the safety and efficacy of Embozene® Microspheres for uterine fibroid embolization to Embosphere® for symptomatic relief from uterine fibroids.

Treatment of Complex Regional Pain Syndrome type 1: A randomized placebo controlled double-blind study with ARA 290, The CRPSARA Study

Study AimsPrimary Aim: This is a proof-of-concept study to evaluate the effect of ARA 290 in pain of patients with CRPS1 by means of once daily subcutaneous injection with ARA 290 for 4 weeks. Secondary Aims: * Assess the predictive effect of…

Management of Acute Rhinosinusitis: Implementation of Guidelines in General Practice

To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.

Cognitive Behavioral Therapy and Mindfulness Based stress Reduction Therapy for Anxiety and Depression Symptoms in Adults with Autism Spectrum Disorders

The central question is: are the recently published treatment methods (a) cognitive behavioral therapy (CBT-ASD) (Schuurman 2011), and mindfulness based stress reduction (MBSR-ASD) (Spek 2011) effective interventions to reduce anxiety and depression…

A multi-center, parallel-group, double-blind, placebo-controlled single and multiple dose escalation study to assess the safety and tolerability and the pharmacokinetic properties of SAR228810 given as IV infusion or as SC injection in patients with mild to moderate Alzheimer*s Disease.

- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IV doses of SAR228810 in…

Transmural Collaborative Care: Depression and Anxiety Disorders with concomitant physical symptoms

To compare transmurale collaborative stepped care with care as usual for patients with a depression or anxiety disorder with five or more concomitant physical symptoms.

A Phase 3, Multicenter, Randomized, Double-blind, Active-controlled, Parallel-group Trial with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Oral E5501 versus
Eltrombopag, in Adults with Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenic Purpura)

Core StudyPrimary objective• To compare the efficacy of E5501 (in addition to standard of care) to eltrombopag (in addition to standard of care) for the treatment of adult subjects with chronic immune thrombocytopenia (idiopathic thrombocytopenic…

Effects of glutamine and epigallocatechin-3-gallate on glucose tolerance, markers of inflammation, oxidative stress and procoagulant status in Type 2 diabetes mellitus

In this pilot study, the objective is to show an improvement in glucose tolerance,a decrease in parameters for inflammation, oxidative stress and a procoagulant state after 4 weeks of daily supplementation of L -glutamine and Epigallocatechin-3-…

A prospective randomised controlled study to evaluate ankle dorsiflexion after cast immobiliation and percutaneous gastrocnemius lengthening, for neurologic healthy children (6-18) with an symptomatic equinus contracture.

By making this design study we wish to contribute to profound research on percutaneous gastrocnemius lengthening for for children with an equinus contracture and prevent publication bias for this open-labelled randomized trial.

Coronally advanced flap combined with Geistlich Mucograft for the treatment of recession type defects: a randomized controlled clinical trial.

As stated before, the aim of this study is to investigate CAF + CM compared to CAF + FCTG for single or multiple maxillary Miller class I and II recession defects in healthy patients. In this way we can get more insight in patient and surgical site…

The effect of baclofen on food craving scores and binge eating episodes in obese subjects

To establish the efficacy of 60 mg baclofen compared to placebo in inducing a decrease in food craving, as assessed by a food craving questionnaires (G-FCQ-T) over 6 months in obese subjects.

Removal versus retention of the syndesmotic stabilisation screw in the ankle: a randomized controlled trial.

The main objective of the study is to compare the routinely removal versus retainment of the syndesmotic stabilization screw.