136 results
The main objective of the trial is to show that ABVD-based response-adapted therapy for advanced-stage Hodgkin lymphoma, with treatment intensification (BEACOPP) in case of a positive FDG-PET after one cycle of ABVD, has non-inferior efficacy…
The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…
We want to investigate wether a para-vertebral block contributes to a reduced postoperative pain and morphine consumption in patients with breast cancer after a unilateral mastectomy or lumpectomy. By doing this investigation we hope to clarify,…
To assess the efficacy, measured as progression free survival, and safety of Selumetinib in combination with docetaxel, compared to docetaxel alone, in patients receiving second line treatment for KRAS mutation negative locally advanced or…
The primary goal of this study is to investigate the effect of low doses of mirtazapine and quetiapine on sleep, assessed using polysomnography and subjective sleep measures, of healthy subjects whose sleep will be disturbed by auditory stimuli (…
Focusing on disease-modifying rather than etiologic mechanisms may accelerate the development of novel therapies and complement current research initiatives on causative mechanisms and curative therapies.
The purpose of this research is to acquire a better understanding of the pain experience and the recovery of children between 1.5 and 5 years old who underwent a tonsillectomy/adenotonsillectomy. Primary research question: What is the influence of…
1. Patients with patent stents will have improved AVP and improved flow in CFV; 2. Patients with stent occlusion will have significantly higher AVPs and lower flow in CFV than patients without stent occlusion; 3. (Pain-free) walking distance will…
Primary aim of the study is to investigate if motivational interviewing can be an effective way to motivate en stimulate patients with recent TIA or ischemic stroke to change their lifestyle and maintain this healthy lifestyle. Moreover we will…
To optimize the quality and cost-effectiveness of care for jaundiced neonates in the Isala Klinieken.
investigate the value of percutaneous pulsed radiofrequency, applied to the lumbar and sacral dorsal root ganglion; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-operated…
Primary Objective is to evaluate the efficacy of solifenacin 5mg in combination with mirabegron 50mg (referred to as combination therapy from here on) versus solifenacin 5mg monotherapy.Secondary Objectives are:- To evaluate the safety and…
In this randomized controlled clinical trial we aim to apply the-already investigated-concept of immediate loading protocol and examine the performance of implant-retained overdentures using 2 SLAactive Straumann implants connected by bar ( Contol…
To test the hypothesis that The Transporters will show significant more improvement in contextual understanding of emotions and social functioning in children with ASD and BIF than a control intervention.
To evaluate the course of psychological emotions, from the active treatment period until the first pregnancy test result, in IVF patients participating in a randomized controlled trial comparing two different IVF treatments (ENDO-RECEPT).
Primary objectiveThe primary objective of this trial is to compare TauroSept® (taurolidine 2% solution) with saline solution 0.9% as catheter lock solutions to prevent catheter-related bloodstream infections (CRBSI) in patients on home parenteral…
The primary objective of this study is to investigate the effect of a meal-like amount of dietary protein prior to sleep on postprandial muscle protein synthesis in healthy young and elderly men, following exercise, during the night. Furthermore, as…
The primary objective of this study is to assess the effect of individualizing the growth hormone dose versus standard treatment with 1 mg/m2/day on adult height. Secondly, we want to assess the first and five year growth response, the long term…
The aim of this study is to investigate the effectiveness of the Phystrac in people with Carpal Tunnel Syndrome.The primary research question is:- Is there evidence that Phystrac might be an additional non-invasive option of treating CTS patients…