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The Diabetes Body Project: Multi-site trial of a virtually delivered eating disorder prevention program for young females with type 1 diabetes

We aim to investigate the efficacy of a novel eating disorder prevention program, the Diabetes Body Project, specifically targeting young females T1D. Firstly, we will test the hypothesis that Diabetes Body Project will produce significantly greater…

The feasibility and potential efficacy of adding Tobacco Treatment using EMDR (ToTEM) to a regular smoking cessation program;A pilot randomized controlled trail in inpatient daily smokers with a substance use disorder

Objective: to investigate areas of uncertainty about a possible future definitive RCT using AF-EMDR as an add-on intervention to a Smoking Cessation Program (SCP), by determining:• Feasibility/process outcomes (e.g. recruitment, adherence, treatment…

Effect of low dose galacto-oligosaccharides (GOS) on faecal gut microbiota in adult women

The primary objective is to investigate the effect of a 3 week intervention with either 1.,3 gram or 2 gram of GOS on the abundance of the genus Bifidobacterium in faecal samples in healthy women of 40 - 70 years old. The secondary objective is to…

A Partially Double-Blinded Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of AST-004 as a Short Loading Intravenous infusion Followed by AST-004 as a Continuous Infusion in Healthy Adult Subjects.

Primary objective:• To evaluate the safety and tolerability profile of single intravenous doses of AST-004 given as a short loading intravenous infusion followed by a 6-hour continuous intravenous (IV) infusion in healthy adult subjects.Secondary…

Acupuncture for Nasal Congestion in Allergic Rhinitis: An Open-Label, Randomized, Monocenter Trial (ANCAR Trial)

To evaluate the effects of an acupuncture treatment protocol for nasal congestion in AR.

A randomized, single-blind, placebo-controlled study to evaluate an oral cholera vaccination with intranasal rechallenge as adaptive immune challenge model

• To characterize the systemic response to mucosal immunization with an oral cholera vaccination challenge.• To characterize the local response to intranasal rechallenge after cholera vaccination as outcome measure for nasal mucosal immunity.• To…

A Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Nebulized Bacteriophage Treatment in Outpatient Adult Cystic Fibrosis (CF) Subjects with Chronic Pseudomonas aeruginosa (PsA) Pulmonary Infection

Primary Objective:To evaluate the safety and tolerability of nebulized BX004-A in CF subjects with chronic PsA pulmonary infection.Exploratory Objective:To evaluate the effect of BX004-A on sputum PsA burden, lung function, frequency of APEs, and…

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study with an Open-Label Extension to Evaluate the Efficacy and Safety of Oral Rilzabrutinib (PRN1008) in Adults and Adolescents with Persistent or Chronic Immune Thrombocytopenia (ITP)

Primary Efficacy Objective (Blinded Treatment Period)• To demonstrate the efficacy of rilzabrutinib versus placebo in participants with refractory/relapsed ITP, based on the durability of platelet response during the last12 weeks of the 24-week…

Safety and Viability of an E. coli Nissle Colibactin Knockout in Healthy Volunteers: A Randomised Controlled Safety Study

Assess the safety and tolerability of the EcNΔClbP strain relative to the EcN wildtype strain following a 1-week daily administration, through questionnaires, medical examination and measurement of inflammatory markers.

The effect of acute stress on executive functioning and decision-making in healthy military personnel.

To study if acute stress has a significant effect on executive functioning scores in healthy military personnel.

DIRECT-2: Fasting mimicking Diet Program to ImpRovE ChemoTherapy in HR+, HER2- breast cancer

To improve the pathological response rate according to Miller and PayneTo improve quality of life including cognitionTo determine the effect of FMD on local tumor immunity