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Comparison between Direct Oral Anticoagulation (DOAC) Interruption and DOAC Continuation in Patients Undergoing Elective Invasive Coronary Angiography or Percutaneous Coronary Intervention

The aim of our study is to study the safety of continued DOAC use during ICA or CAG in elective procedures, by comparing the risk of in-hospital and 30-day bleeding complications between continued and interrupted DOAC use.

Grip on knee Osteoarthritis; DIstraction Versus Arthroplasty (GODIVA) for young knee osteoarthritis patients in regular care.

To determine whether KJD is non-inferior on patient reported effectiveness as compared to a KP (i.e. usual care) for relatively young patients with end-stage knee OA. For the substudy: the primary objective is to predict the benefit from knee…

Aerobic fitness or Muscle mass training to Improve Colorectal cancer Outcomes (AMICO): to study safe and feasible exercise dosages (phase 2) and the effects of exercise on chemotherapy dose modifications and progression free survival (phase 3) in patients with metastatic colorectal cancer.

Phase 2 pilot-study: to examine feasible exercise dosages in patients with mCRC and collect data on preliminary effects on clinical outcomes.Phase 3 trial: to collect data on the efficacy of exercise on 1) chemotherapy dose modifications and 2)…

Bifurcation PCI with a hybrid strategy with drug eluting balloons versus a stepwise provisional two-stent strategy. A randomized controlled single-blinded multicentre trial and registry

In this study we will compare a hybrid DEB strategy with a conventional bailout 2-stent strategy (TAP/T-stenting or Culotte) in patients with a bifurcation lesion with sub-optimal side-branch result. The primary endpoint will be the composite…

The safety and cost-effectiveness of discontinuing disease-modifying therapies in stable relapsing-onset multiple sclerosis (DOT-MS): a randomized rater-blinded multicenter trial.

The aim of this study is to identify whether it is possible to safely discontinue treatment in stable RRMS patients who have shown no evidence of active inflammation in the years prior to inclusion in terms of the return of inflammatory disease…

Enhancing effect of dual interventions versus conventional TMS in the treatment of
depression

rTMS is an intensive but effective treatment that could benefit from further optimization. Cognitive control training (CCT) engages the same underlying neural circuitry as rTMS and has been shown to improve therapeutic response (Koster et al., 2017…

Thrombectomy in high-Risk Pulmonary Embolism - Device
versus thrombolysis Netherlands: TORPEDO-NL

To determine whether CDT in high-risk PE relative to systemic thrombolysis is:- more effective and safer in terms of a reduction of the composite endpoint on all-cause mortality and adverse events defined as treatment failure, major&…

Early detection of symptoms using digital patient-reported symptom monitoring and a Fitbit to optimize care in metastatic breast cancer (SYMPHA, BOOG 2024-01).

This study aims to determine the effect of real-time symptom monitoring on HRQoL in patients with mBC who start first-line chemo(immune)therapy. Further objectives include analyzing the effect of PRS monitoring on physical functioning, the severity…

RUTI-FREEDOM: Recurrent Urinary Tract Infections in Females Receiving Effective Education, Digital Outreach & Management - a multicenter prospective randomized controlled trial in the Netherlands

A pilot study on digital coaching in rUTI at the Urology Department of Isala tested an app-based treatment additional to standard care.[8] The app provides information on rUTI aetiology, lifestyle recommendations, treatments, and the value of…