5992 results
The primary objective is to demonstrate superiority in overall survival of amrubicin (40 mg/m2 administered as a 5-minute infusion once daily for 3 consecutive days starting on Day 1 of a 21-day course) compared with topotecan hydrochloride (…
To examnine the effectiveness of psychological interventions and psychopharmacological interventions compared to placebo-control.
The aim of this trial is to determine the effectiveness of an operation (decompressive craniectomy), compared to medical management alone, to treat brain swelling and improve outcome. The results of this trial will better define the indications for…
Concomitant AF ablation with HIFU in patients with persistent or long standing persistent AF undergoing CABG will be superior in restoring SR, compared with patients with persistent or long standing persistent AF undergoing CABG treated with best…
Primary Objective: • The primary objective of the study is to evaluate the efficacy of three doses of atacicept to reduce CNS inflammation in subjects with RMS as assessed by frequent MRI.Secondary Objectives: • Evaluate safety and tolerability of…
The aim is to understand which individuals benefit from antibiotics.
Primary:to assess the reduction of initial study drug Cmax after administration of 20 mg study drug 10% SRF using three modified formulations as compared to the current Phase 3 formulation in healthy volunteers.Secondary:to assess the safety and…
Primary Objective: To investigate the effect of treatment with nebulized rhDNase on pulmonary function in children with asthma and persistent obstructive pulmonary function.Secondary Objectives: To investigate the effect of treatment with nebulized…
This study will test the following hypotheses:Primary: The DirectLife program is effective in increasing the level of physical activity in an ageing populationSecondary:1. The level of physical activity associates with parameters of 24-hour glucose…
The purpose of this study is to identify the first time-point the OMERACT RAMRIS score for the activity of synovitis is statistically significantly reduced compared to Baseline, in response to cerolizumab pegol (CZP) therapy. In addition, the early…
To investigate the effectiveness of an internet physical activity / self-management program (artroseinbeweging.nl).
To compare the efficacy of playing Tetris to Assessments Only in the reduction of frequency, vividness, and emotional intensity of intrusions in Dutch soldiers exposed to aversive events on deployment in Afghanistan.
The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and…
A pilot feasibility study (n=5) will be performed to evaluate the feasibility (logistics, timing) and safety of administering autologous tumor infiltrating lymphocytes (TIL) generated at the NKI-AVL infused in conjunction with systemic high-dose…
Primary objective:To identify the neural mechanisms via which oxytocin modulates social decision-making.Secondary objectives:- To provide an extension of observed behavioral effects of oxytocin on decision-making, specifically to examine decisions…
To determine whether fibrinogen concentrate infusion reduces perioperative blood loss and transfusion in patient experiencing clinically relevant microvascular bleeding during elective complex cardiac surgery and to determine whether its use is safe…
To optimize independent functioning and quality of life through:1. Systematic screening for increased risk of functional loss among community dwelling elderly (Phase 1);2. Providing a nurse-led, complex intervention to elderly people with an…
The general objective of this project is to evaluate, for persons with a SCI, on the short and long term, the added value of a behavioural focused intervention, on top of a physical exercise intervention, on the level of everyday physical activity.…
Primary ObjectivesThe primary objectives of this study are to establish:1. The efficacy of internet-delivered SMT for chronic migraine - compared to waitlist control- regarding the post-training improvement of migraine attacks and headache days per…
Tissue hypoxia occurs frequently during high-risk surgery in high-risk patients. We want to see if an algorithm aimed at optimizing intraoperative tissue oxygenation reduces perioperative complications as well as length of stay in the intensive care…