2656 results
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
To assess the impact of using breathing instructions while performing motion-compensated MR imaging of lesions in the thorax or abdomen aimed at radiotherapy treatment planning as compared to motion-compensated scans without instructions and free-…
The main aim of the current study is to assess the optimal protein intake that maximizes whole-body protein net balance in healthy, young adults.
The primary objective is to investigate the involvement of the GABA-A receptor in behavioral and neural measures of conscious perception, cognition, and decision-making.
The primary aim of this study is to investigate the effect of four different degrees of arch support on arch compression and running economy. Moreover, as a secondary aim, this study also examines the effect of bending location on running economy.…
The primary objective of this study is to isolate effects of dopamine receptor manipulation on distinct forms of working memory (WM) gating and their associated physiological changes in distinct layers of prefrontal cortex (measured with high-…
The present study compares the postprandial amino acid uptake kinetics between a commercially available (fermented) yoghurt versus a commercially (full fat pasteurized) milk matched for protein and volume.
Primary Objectives: Quantify the PD effects of CNS active compounds with distinct mechanisms of action (lorazepam, modafinil and S-ketamine) with NeuroKit and NeuroCart in healthy male and female participants. Estimate the…
The aim of the PISCES study is to evaluate the long-term effectiveness of SCS by comparing a paresthesia-free form of stimulation that the patient does not feel, with sham stimulation in which no stimulation is given. The study will focus on…
The primary objective of the study is to assess the performance of the updated algorithm software. The secondary objectives are to assess the safety and other performance parameters of the updated software algorithm. Additionally, another secondary…
In this study, we investigate how two new measurement methods can demonstrate the effects of two existingdrugs, modafinil and alprazolam, on the excitability of the brain. We test these effects only in healthy subjects.The effects of modafinil and…
The primary objective is to study whether a microparticulated whey protein shake shows a non-inferior incremental area under the curve (iAUC) of the plasma total essential amino acids (TEAA), up to 300 minutes after protein consumption, compared to…
The purpose of this study is to investigate how the uptake and elimination from the body (this is called pharmacokinetics) of a combination oral contraceptive (COC; 100 µg levonorgestrel and 20 µg ethinyl estradiol) is affected by the…
Primary objective: to determine if a plasma lycopene concentration can serve as a response parameter after a single dose of dietary lycopene.
The general objective of this study is to investigate whether ketone monoester supplemention improves cognition. Cognition will beassessed by adaptive n-back test and task-switching test. The study will also investigate the effect of ketone…
Primary: effects of SAF312 on the Maximum Cystometric Capacity (changes from baseline) versus placebo following one-week treatment.Secondary: Evaluation of the safety, tolerability and PK, PK/PD, additional parameters examined during cystometry,…