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Follow-Up after feToscopic sURgical intErventions: the FUTURE study

Both RCTs and long-term follow-up studies are required to establish optimal fetal management and provide clinicians a better understanding of the impact of these early interventions on child development in order to improve the quality of antenatal…

Long-term follow-up of the prospective and comparative study of the performance of tension free vaginal mesh (ProliftTM) versus conventional pelvic organ prolapse surgery in recurrent prolapse

To asses the effectiveness of surgery 7 and 10 years after conventional vaginal POP surgery compared with tension free vaginal mesh.

Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

STATEC: A randomised trial of non-selective versus selective adjuvant therapy in high risk
endometrial cancer

To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by full lymph node dissection.

Prospective study on the treatment of congenital vaginal agenesis or vaginal hypoplasia - genital reconstruction, gynecological and urological aspects, psychosexual and social aspects and quality of life

Evaluation study on the effectiveness of a new developed vaginal dilatation programme for medical-psychological treatment of vaginal hypoplasia / agenesis.

The role of immunology in diabetes mellitus and pregnancy

Primary Objective: To determine the local and peripheral immune response in diabetic pregnancies in comparison to healthy controls. Immune response will be measured by counting Th1/Th2-cells, Tregs, NK-cells, monocytes and granulocytes. Produced…

Sacrospinous ligament fixation or Elevate Posterior procedure in treatment of primary apical prolapse stage * 2: a matched cohort study.

To compare the effects of Elevate Posterior procedure versus sacrospinous ligament fixation on pelvic floor function.

In vitro maturation of human oocytes with subsequent IVF or ICSI . An observational study with follow up of the children.

The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…

Is Uracyst effective to prevent or reduce acute radiation cystitis in patients who are treated with radiotherapy for gynaecologic malignancy?

The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.

STATEC: A randomised trial of non-selective versus selective adjuvant therapy in high risk apparent stage I endometrial cancer

To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by fulllymph node dissection.

Sentix: A prospective observational trial on sentinel lymph node biopsy in patients
with early stage cervical cancer

To evaluate whether a less radical surgical approach with sentinel lymph node biopsy is non-inferior to treatment with systematic pelvic lymphadenectomy.The null hypothesis is that the recurrence rate after SLN biopsy is non-inferior to the…

Maternal psychological Outcome after Multifetal pregnancy reduction

The primary objectives of this study are 1) to assess the factors and considerations that play a role in the decision-making process of either multifetal pregnancy reduction or maintaining a multifetal pregnancy, and 2) to assess the emotional…

The short and longterm effects of posterior colporrhaphy; the role of levator sutures.

To determine the long and short term outcomes of posterior colporrhaphy with and without levator sutures. To compare both groups and maybe give a scientifically proven answer to the question which one has a better outcome. Then we can offer our…

The vasoactive role of TRPV1, TRPA1 and TRPM3 in human dermal arteries

In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…

SUperiority of Perineoplasty as concomitant surgical procedure during Pelvic Organ prolapse Repair: a comparative cohort Trial (SUPPORT)

This study aims to demonstrate superiority of the research intervention (over standard of care) in [1] surgical success and [2] cost-effectiveness and non-inferiority in morbidity

Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma. A multicentre observational study.

The primary objective is to investigate the safety of replacing complete IFL by the SLN procedure in patients with local recurrent vulvar squamous cell carcinoma without suspicious groin lymph nodes.

Surgery or Medication for women with Endometrioma.

What is the effectiveness and cost-effectiveness of surgical treatment of women suffering from pain due to an endometrioma when compared to treatment with medication?