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The incidence of (para) thyroid disorders ten years after the introduction of a new thyroid protection during 131I-MIBG treatment in children with neuroblastoma

Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…

Genome-wide sequencing for the identification of potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma in children

To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.

Effects of thyroid hormone treatment on mitochondrial function, ectopic fat accumulation, insulin sensitivity and brown adipose tissue in type 2 diabetes mellitus

The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…

Aberrant receptor expression in thyroid tissue: A role in the pathogenesis of multinodular goiter?
A pilot study

ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…

The retro-orbital fibrobast: a key player in Graves* opthalmopathy and a target for therapy.

Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.

An International, Randomised, Double-Blind, Two-Arm Study to Evaluate the Safety and Efficacy of Vandetanib 150 and 300 mg/day in Patients with Unresectable Locally Advanced or Metastatic Medullary Thyroid Carcinoma with Progressive or Symptomatic Disease.

The primary objective of this study is to assess the objective response rates (ORR) for two starting doses of vandetanib, 150 mg and 300 mg in patients with unresectable locally advanced or metastatic MTC having progressive or symptomatic disease.…

Coagulation and fibrinolysis in patients with resistance to thyroid hormone due to a thyroid hormone receptor β-gene mutation

To investigate the effect of resistance to thyroid hormone (RTH) due to a TRβ mutation on coagulation and fibrinolysis

Hypo vWf: hypothyroidism and Von Willebrand factor.

This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.

Evening versus Morning Administration of Levothyroxine: a randomised controlled double-blind trial

To study in a large randomised double-blind trial, if the administration of levothyroxine at bedtime significantly changes TSH and thyroid hormone levels compared to morning administration. Furthermore we want to evaluate the change of quality of…

Study on the effects of thyroid hormone on renal tubular kreatinine excretion

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Oral Thyroid hormone In Healthy volunteers Study: an interventional study on the effect of thyroid hormone on coagulation and fibrinolytic parameters.

Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…

Markers of airway inflammation in auto-immune hyperthyroidism; the interaction between thyroid and airways

Hypothesis:In auto-immune hyperthyroidism there is an increase of (eosinophil)airwayinflammation compared to healthy test subjects.Objective:testing our hypothesis by answering the following questions:1. What is the difference in NO in exhaled air…

Clinical Management of patients with Afirma® Gene Expression Classifier for Thyroid Nodules with Indeterminate FNA Cytopathology

Objective: The purpose of this study is to compare the diagnostic surgical rate of a matched control group, derived from a retrospective review of patients without GEC testing, with a prospective GEC tested group.

Effect of treatment with levothyroxine in a patient with thyroid hormone receptor *1 deficiency

Objective: The primary objective of the study is to determine the effect of standard treatment with levothyroxine in TR*1 deficiency on:- Neutrophil and macrophage function- Erythropoiesis- Thyroid hormone target gene expression- Plasma metabolome

A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second line therapy for patients with eitherc differentiated and medullary thyroid carcinoma progressing after first line therapy.

The primary objective is to explore the efficacy of nintedanib (as measured by progression free survival) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.

Insights into the pathophysiology of Hashimoto thyroiditis: Assessing thyroid Reserve capacity & the role of the Gut micrObiome in thyroid hormone metaboliSm

Primary objective: To assess and compare the difference in thyroid gland secretion capacity by measuring maximal FT4 and FT3 response upon intramuscular administration of 0.9mg Thyrogen assessed by AUC0-48hours in SCT subjects and healthy controls.…

Determinants and mediating mechanisms of quality of life and disease-specific symptoms among thyroid cancer patients: the WaTCh study

Our main objective is to assess QoL and disease-specific symptoms over time. Our secondary objectives are to identify demographic, environmental, biological, physiological and personality characteristics of TC patients who are at high risk for poor…

The Butterfly-study: The Detection of Thyroid Cancer via VOCs using GC-IMS

The main objective of the research is to differentiate between benign and malignant thyroid nodules using the GC-IMS for the analysis of breath, urine and blood in a (multicenter) study and reduce the amount of unnecessary surgery.

Improvement of laboratory diagnostics in hypothyroid patients using levothyroxine.

The aim of this study is to identify whether we can improve laboratory diagnostics in patients with hypothyroidism receiving thyroid hormone supplementation. We will investigate whether, in addition to the current laboratory tests of TSH and fT4,…

Comparison of two methods to improve the outcome of a ultrasound assisted fine needle aspiration biopsy (FNAB) of the thyroid gland.

Primary objective: - obtain an comparison in diagnostic results of two methods of ultrasound assisted fine needle aspiration biopsies (FNAB) of the thyroidal gland in the Jeroen Bosch hospital (JBZ).Secondary objective:- can the cytological thyroid…