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Randomized, Placebo-controlled Double-blind Cross-over Study to Evaluate the Effects
of Oligofructose on Stool Frequency in Constipated subjects

To study the effect of fructo-oligosaccharides on functional constipation.

The effect of glycopyrroniumbromide on nocturnal clozapine induced sialorrhea in psychiatric patients: a randomized, cross-over, double blind, placebo controlled trial with an extended open label phase (QUITSPIT study)

Main objective: to determine the effect, defined as the percentage of patients that show a clinical relevant improvement on the severity of complaints of nocturnal sialorrhea, of oral glycopyrroniumbromide in comparison with placebo in psychiatric…

The effects of ethanol on gut wall integrity as measured by I-FABP and LBP

The aim of this study is to determine the immediate effects of oral alcohol consumption in healthy volunteers on gut wall integrity as measured by Intestinal Fatty Acid Binding Protein (I-FABP) and Lipopolysaccharide Binding Protein (LBP) These…

Desensitisation of ulcerative colitis patients intolerant for mesalazine treatment.

Primary endpoint:- Successful desensitization for Mesalazine in ulcerative colitis patients with a presumed history of intolerance for Mesalazine. Secondary endpoint:- To investigate if a presumed intolerance for Mesalazine may be reproducible in a…

A double-blind, randomized, placebo-controlled, two-centre, phase IIa pharmacodynamic cross-over study to assess the effect of AZD2516 on the total number of reflux episodes in healthy male volunteers

The primary aim of the study is to determine the effect of orally administered AZD2516 as a reduction of the number of reflux episodes, in comparison with placebo, over a period of approximately three hours after a meal, in healthy male volunteers.

A Double-Blind, Placebo-Controlled, Single Ascending Dose Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CCX507-H in Healthy Male and Female Subjects

Primary:to evaluate the safety and tolerability of single oral doses of CCX507-H, over a range of 3 dose levels, in healthy male and female subjectsSecondary:to evaluate the following:* Single dose pharmacokinetic profile (PK) of CCX507-H over a…

Effect of amitriptyline in functional heartburn

To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.

The effect of capsaicin and cinnamaldehyde on intestinal permeability, gallbladder motility and satiety

To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…

The effect of moderate alcohol consumption on a human in vivo model of low-grade systemic inflammation in young, normal-weight men

Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…

The effect of ethanol on intestinal permeability and integrity in healthy individuals

The study aims to investigate the effects of moderate ethanol drinking on the intestinal permeability and the tight junction complex. If there increase in the intestinal permeability, these effects will be investigated at molecular level.

A phase 3, Multi-Center, Randomized, Placebo-Controlled Study to Evaluate the Clinical Efficacy and Safety of Induction and Maintenance Therapy with Abatacept in Subjects with Active Crohn's Disease (CD) who have had an Inadequate Clinical Response and/or Intolerance to Medical Therapy

Primary ObjectivesPlacebo-Controlled Induction Period: Primary Objective: Compare the proportion of subjects who have a clinical response (as defined by a reduction in Crohn*s Disease Activity Index [CDAI] >= 100 or an absolute CDAI score…

A Phase III, Multi-Center, Randomized, Placebo-Controlled Study to Evaluate the Clinical Efficacy and Safety of Induction and Maintenance Therapy with Abatacept in Subjects with Active Ulcerative Colitis (UC) who have had an Inadequate Clinical Response and/or Intolerance to Medical Therapy

Placebo-Controlled Induction Period Primary Objective: Compare the proportion of subjects who have a clinical response at Week 12 between the abatacept and placebo treatment regimens.Maintenance Period Primary Objective: Compare the proportion of…

The effect of serotonergic modulation on intestinal permeability and visceral perception in healthy individuals and IBS patients

We would like to modulate the serotonin system with acute tryptophan depletion (ATD) and 5-hydroxytryptophan (5-HTP). ATD is based on ingestion of an amino acid drink devoid of the precursor of serotonin and hence caused a decreased serotonin level…

The safety and gastro-intestinal tolerance of recombinant human lactoferrin (rhLF) in apparently healthy human volunteers

To study the safety and digestive tolerance of recombinant human Lactoferrin (rhLF) as expressed in milk of transgenic cattle.

Effect of Dientamoeba fragilis eradication on symptoms in children with abdominal pain

Effectiveness of treatment with clioquinol on parasitologic eradication is being studied as well as the clinical effectiveness of eradication in children with dientamoeba fragilis infection.

A randomised, single dose, crossover, open label, placebo controlled confirmatory study with interim analysis in healthy volunteers to characterise the acid neutralisation activity of Gaviscon Double Action Tablets in the fasted state, using an intragastric and oesophageal pH catheter

The primary objective of this confirmatory study is to investigate the acid neutralisation action of Gaviscon Double Action Tablets versus placebo tablets, within the stomach.The secondary objective of this study is to assess the safety of the test…

The effect of CanChew®, cannabidiol (CBD) containing chewing gum on Irritable Bowel Syndrome

Investigate the effect of administration of CBD by means of CanChew® chewing gum versus a placebo on pain, IBS symptoms and perceived wellbeing in patients with IBS.

The effect of Iberogast on heartburn in patients with functional dyspepsia

To assess the effect of Iberogast on heartburn, the incidence of reflux episodes and oesophageal sensitivity in patients with functional dyspepsia.

In vivo effects of amylase trypsin inhibitors from wheat in the human gut: proof of cause of non-coeliac wheat sensitivity in irritable bowel syndrome?

We aim to perform a proof-of-concept study to assess the effect of ATIs on the intestinal barrier and immune function in healthy volunteers. We hypothesise that the ATIs either directly affect the intestinal barrier function, or indirectly by…

Postprandial Lipids in IBS and Nutritional Treatment

The primary objective of this study is to determine the effect of short-term Turmipure GOLD® supplementation on LPS translocation in IBS-D and IBS-M patients after a high-fat challenge.The secondary objective of this study is to determine the effect…