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Acute effects of 40 mg cortisol on emotion and cognition.

To investigate acute effects of a single 40 mg dose hydrocortisone, compared with placebo, on stress and various aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy anxious young females. The main question…

Boosting oxytocin after trauma: The effects of intranasal oxytocin administration on emotional and motivational brain processes in PTSD

In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…

Acute effects of 40 mg cortisol on mental functions II

The closer examination of acute effects of a single administration cortisol. compared to placebo, on different aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy young men. The central question is what…

Effect of testosterone administration in Social Anxiety Disorder.

A phase 1, single centre, single dose, double-blind, double-dummy, four-way crossover, placebo-controlled, randomized study to investigate the effects of AZD7325 on sedation, cognition and EEG in comparison with lorazepam in healthy male volunteers.

This study is being performed to document the effects of the new compound AZD7325 on brain functions and to investigate whether it has fewer side-effects compared lorazepam.

Acute effects of a single dose 40 mg cortisol on mental functions.

To further study effects of a single administration of cortisol, compared to placebo, on different aspects of attention and other cognitive processing of emotionally relevant information in healthy young men. This should provide new information on…

The role of adrenal stress hormones in emotional memory: formation, consolidation, and reconsolidation

-Identify the neural correlates of enhanced formation of emotional memory, and parse the role of adrenal stress hormones in this process.-Identify the neural correlates of enhanced consolidation of emotional memory and parse the role of adrenal…

A 2-Part, Randomized, Double-blind, Double-Dummy, Placebo- and Active Comparator-controlled, Repeat Dose Study to Establish Proof-of-Concept of GRX-917 in Experimentally Induced Panic and to Further Characterize its Repeated Dose Pharmacokinetics and Pharmacodynamics in Healthy Subjects

Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…

Targeted glucocorticoid administration to improve safety learning in PTSD patients with HPA axis dysregulation

This study has been transitioned to CTIS with ID 2024-516427-13-00 check the CTIS register for the current data. Substudy A: The primary objective will be to investigate the relationships between HPA axis dysfunction, early life adversity (ELA), and…

A randomized, double-blind, placebo- and active comparator-controlled, crossover trial to examine the effect of multiple doses of CVL-865 on panic symptoms induced by carbon dioxide inhalation in healthy subjects

Primary: To investigate if CVL-865 decreases subjective anxiety symptoms elicited by a 35% CO2 inhalation challenge.Secondary: To investigate if CVL-865 decreases subjective fear symptoms elicited by a 35% CO2 inhalation challenge. To investigate if…

Early-life stress, the endocannabinoid system, and fear memory extinction

Primary objective: Our key objective is to determine if a cannabinoid manipulation is more effective than a glucocorticoid manipulation to facilitate fear memory extinction retention in an experimental model of exposure therapy in healthy…

A Randomized, Placebo-controlled, Double-blind, Multiple Ascending Dose Study to Investigate
Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy
Subjects.

The primary objectives are:- To investigate the safety and tolerability of JNJ-61393215 after multiple consecutive dose administrations;- To characterize the pharmacokinetics (PK) of JNJ-61393215 in plasma after multiple consecutive dose…

A Multi-cohort, Randomized Study in Healthy Subjects to Assess the Pharmacokinetics and Safety of Single and Multiple Ascending Doses of JNJ-61393215 (Suspension), and to Assess the Relative Bioavailability, and the Effect of Food on the Pharmacokinetics, of a New Solid Formulation (Capsules) of JNJ-61393215

This study will be performed in 56 healthy volunteers. The study will be performed in 3 parts, Part 1, Part 2 and Part 3. Part 1 will be performed in 16 healthy volunteers divided over 2 groups of 8 volunteers each. The purpose of Part 1 of the…