9 results
Primary Objective: To assess the change from baseline in 24-hr albuminuria with dapagliflozin for six weeks relative to placebo treatment in patients with diabetes and albuminuria > 100 mg/day on stable ACEi or ARB treatment.Secondary…
Determinination of the added effects of dietary sodium restriction or diuretic use to antihypertensive and antialbuminuric therapy.
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…
To assess whether dietary nitrate supplementation blunts the ischemia-reperfusion-induced rise in cTnT levels following exercise in type 2 diabetic patients.
To estimate the effect of rosiglitazone compared to placebo on ischemia-reperfusion injury as assessed by annexin A5 scintigraphy in the human forearm in subjects with the metabolic syndrome.
Primary: To determine the individual response to the SGTL2 inhibitor dapagliflozin in urine albumin-to-creatinine ratio (UACR) Secondary:- To determine the individual response to the SGLT2 inhibitor dapagliflozin in: - Systolic blood pressure - Body…
In one of our previous study we demonstrated that enhanced acetate availability in the distal, but not proximal, colon promote fat oxidation, energy expenditure and parameters of substrate and energy metabolism in healthy normoglycaemic men. In…
Primary objective: to study whether pyridoxamine supplementation in type 2 diabetes improves microvascular function in the eye, kidney and skin, and reduces markers of endothelial dysfunction and glycation.Secondary objective: to study whether…
In this randomised, double-blind, placebo-controlled cross-over single centre study we propose to study the effect of duodenal infusion of single E. Hallii treatment of 10 ml 10E9/ml in 10% glycerol or 10ml 10 % glycerol (administered via duodenal…