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Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

Diagnosing exercise induced laryngeal obstruction: The influence of air temperature and humidity on exercise induced laryngeal obstruction (EILO)

To investigate the influence of air temperature and humidity on the occurrence of EILO. A better understanding of the pathophysiologic principles causing EILO could lead to increased sensitivity of CLE testing. New insights in the causes of EILO can…

Natural daylight to improve 24h metabolism and glucose control in type 2 diabetes individuals

The primary objective is to investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in T2DM individuals and to unravel molecular mechanisms underlying effects of natural daylight on circadian clocks and (…

Understanding mechanisms of prevention of depression: a mechanistic cross-over trial of mindfulness vs. fantasizing to reduce perseverative cognition underlying vulnerability for depression

The main objective of study 1 is to test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in a cross-over design in 50 remitted MDD patients vulnerable for depressive relapse. The…

A randomized double-blind sham-controlled trial to evaluate efficacy and safety of REvita® DMR Treatment ParadIgm 1 and RetreatmeNt in patients with type 2 Diabetes using non-insulin glucose lowering medications.

This study consists of the following objections:- To evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham)- To evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks (compared…

Determination of the optimal nutrient mix to acutely increase plasma ketones.

We intend to perform a pilot study to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides, MCTs) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2). Since the aim is to…

The EXPLAIN Study: Exploring plant-based meat analogues for their Impact on health

The primary objective is to evaluate if and to what extend replacing all meat products in an average Dutch diet with currently commercially available PBMAs affects the systolic blood pressure of middle aged men and women in a 2x8 week fully dietary…

The influence of music choice on pain tolerance in the context of social background in healthy volunteers.

The primary objective of this study is the pain tolerance of linear increasing electric stimuli between music and control setting (podcast), especially looking at the social background. Moreover, comparison of the two music interventions, self-…

A Prospective, Randomized Clinical Trial Evaluating INTIBIA (TM), an Investigational Implantable Tibial Nerve Stimulator, Through 24-Months

The purpose of the INTIBIA pivotal study is to demonstrate the safety and effectiveness of the INTIBIA System in the intended population through 24 months of follow-up. Data at 12-months will be used to support regulatory approval.The objective of…

Physiological effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort ain Patients Weaning from Invasive Mechanical Ventilation

Primary Objective: To determine the difference in change in sputum viscoelasticity on HME and HFTO during disconnection sessions from the ventilator in tracheotomised patients. Secondary Objective(s): 1. To determine the difference in respiratory…