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Effect of Carbon Dioxide Enriched Ambient Air on Pharmacokinetics and Deposition In Bronchiectasis Patients Using Tobramycin Inhalation: A proof of concept study.

1. To asses (with planar imaging) whether SPECT/CT scan are feasible in assessing pulmonary deposition of inhaled tobramycin.2. To evaluate the effect of CO2 enriched ambient air on deposition of inhaled tobramycin in bronchiectasis patients.3. To…

Pacing Away From Heart Failure: Left bundle branch area pacing or biventricular pacing in patients with atrial fibrillation and left ventricular dysfunction

Primary objectives:1. To compare LVESV change between LBBAP and biventricular pacing in patients with AF and LV dysfunction.Secondary objectives: 2. To compare change in quality of life, New York Heart Association functional class, 6-minute walking…

Randomized trial comparing steered Deep Brain Stimulation with ring-shaped Deep Brain Stimulation for advanced Parkinson*s disease

To demonstrate that steered STN DBS is more effective than ring-mode DBS in reducing PD motor symptoms and to demonstrate that steered STN DBS has the potential to cause less stimulation-induces side-effects.