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Cost-effectiveness of Early Surgery versus Conservative Treatment with Optional Delayed Meniscectomy in older Patients. A Randomized Controlled Trial.

The objective of this study is to evaluate the effectiveness and cost-effectiveness of surgical and conservative treatment of non-obstructive meniscal injuries in older patientsHypothesis: We assume equal improvement of physical function in both…

Effect of shoe adaptation on pain and ankle motion in patients with post traumatic ankle arthritis

To investigate whether adding a rocker bar (including rounded heel, proximally placed fulcrum and stiffened sole) significantly reduces pain, the range of motion in the ankle and the ankle moments in patients with posttraumatic ankle arthritis.

A single-center, open-label, randomized, 3-way crossover study to evaluate the pharmacokinetic profile and tolerability of Flurbiprofen following administration of two Flurbiprofen transdermal formulations compared to Yakuban Tape® in healthy subjects

The purpose of the study is to investigate to what extent the FTS patches are tolerated. It will also be investigated how quickly and to what extent flurbiprofen from the FTS patch is absorbed and eliminated from the body (this is called…

Lateral C1-2 Joint Pulsed Radiofrequency Application in the treatment of Cervicogenic Headache

The primary objective in this study is to compare the effectiveness of lateral C1-2 pulsed radiofrequency application (LPRF) in comparison with conventional C3-5 facet denervation (MBRF) in patients with clinically defined cervicogenic headache.

Reumates@work; An internet based cognitive behavioural programme to promote physical activity in children with Juvenile Idiopathic Arthritis (JIA).

To improve physical activity levels and physical activity patterns in children with JIA by means of cognitive behavioural training based on the social cognitive theory and the health promotion model, delivered by internet and supported by group…

Comparison between the Manometric brace and conventional plaster braces for patients with osteoarthritis of the trapeziometacarpal joint: a randomised crossover trial

The aim of this randomised crossover trial is to compare the Manometric TMC brace with conventional plaster braces in terms of patient satisfaction, pain, hand function, compliance and patient preference.

A Two-Phase, Multicenter, Randomized Study Comparing Autologous Protein Solution (APS) with Hyaluronic Acid (HA) Intra Articular Injections in Patients with Knee Osteoarthritis (OA)

Primary ObjectiveThe primary objective of this study is to determine whether nSTRIDE APS is superior to HA in mean Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) LK 3.1 pain score (change from baseline to 12 months post-…

A randomized, open-label, two-period, crossover study to determine the pharmacokinetics of reconstituted lyophilized Erelzi and Enbrel® (US-licensed) following a single subcutaneous injection in healthy male subjects.

The purpose of the study is to compare these two drugs in view of how quickly and to what extent the drugs are absorbed and eliminated from the body (this is called pharmacokinetics) after injection under the skin of the abdomen.In addition, it will…