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Psychological interventions for familymember and partners of murdered persons

This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…

Platelet reactivity in diabetic patients and the effects of different antithrombotic agents on the results of multiple platelet function tests

Primary Objectives:1. To compare the magnitude of baseline (or intrinsic) platelet reactivity between T2DM patients and healthy volunteers using multiple platelet function assays 2. To compare the magnitude of baseline (or intrinsic) platelet…

An Open-Label, Randomized Crossover Study to investigate the feasibility and applicability of the WatchBP O3 family from Microlife

The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…

Protein and energy interactions in critically ill children

1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…

Blood Pressure and Cardiac Output - the influence on cerebral perfusion during cardiopulmonary bypass.

To study the influence of systemic blood flow and mean arterial pressure on cerebral blood flow in patients undergoing on-pump cardiac surgery.

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation, and early lung function measurements

This research proposal tests the hypothesis that an early asthma diagnosis is possible by using non-invasive biomarkers of oxidative stress/airway inflammation in exhaled air, venous blood and assessments of lung function (airway resistance by means…

The effectiveness of intensive treatment on sympathetic hyperactivity. A randomized, cross-over trial in patients with chronic kidney disease and hypertension

The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…

A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing selpercatinib (LOXO-292) to Physicians Choice of Cabozantinib or Vandetanib in Patients with Progressive, Advanced, Kinase Inhibitor Naïve, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531)

Primary* To compare TFFS of patients with progressive, advanced, kinase inhibitor naïve, RET-mutant MTC treated with LOXO-292 versus cabozantinib or vandetanib.Secondary* To compare other efficacy outcomes, based on RECIST 1.1 criteria, observed in…

pelvic floor physiothearpy in treatment of anal fissure (PAF-study)

The effect of pelvic floor physiotherapy with biofeedback in patients with anal fissure and pelvic floor dysfunction.

Study on the pharmacokinetic interaction between diclofenac and tamoxifen in patients with breast cancer. "the DICLOTAM study"

Primary objective1. To compare the Area under the curve (AUC) of endoxifen in patients with breast cancer treated with tamoxifen with and without diclofenac.Secondary objectives1. To compare the Area under the Curve (AUC) of tamoxifen and endoxifen-…

Oral, gastric and cognitive contributions to satiation

The primary objective of this study is to determine whether, oral, or gastric feedback is most important for meal termination (satiation). As a secondary objective we aim to understand how cognitive factors modulate the oral and gastric signals and…