47 results
This study is aimed to determine the efficacy of varenicline in reducing EDS in PD patients.
The intended result is the discovery of an more effective, more simple, cheaper and more user-friendly treatment for positional OSA than current therapies. Positional therapies have been used as regular treatment in the Amsterdam Wake Sleep Center.…
To compare the additional diagnostic yield obtained by using the PeerScope System* extended view vs. the diagnostic yield obtained by the Standard view colonoscopy.In addition, time measurements including time to cecum, time for withdrawal and…
Primary objective: To investigate whether pharmacokinetics of the recommended dose of inhaled tobramycin, defined as serum tobramycin Area Under the Curve (AUC0-24hr), with the I-neb (75 mg) is equivalent to the PariLCPlus (300 mg) nebuliser in…
In this trial will be investigated if a new formulation of valacyclovir, e.g. oral solution, is bioequivalent to valacyclovir tablets. This comparison will be made by determining pharmacokinetic parameters (AUC0-*, Cmax, and tmax) of both…
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
To evaluate the proportion of patients indicating an overall preference via a Patient Preference Questionnaire (PPQ) for either the subcutaneous (SC) or the intravenous (IV) route of rituximab administration.
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
Primary Objective: 1. Will an exposure to oxygen with a PO2 = 190 kPa lead to changes primarily in DLno compared to DLco?Secondary Objectives: 1. After an exposure to oxygen with a PO2 = 190 kPa for one hour, are the changes primarily located in the…
Previously we have shown that visual field defects in hemianopes can be reduced by visual training and that it improves performance in daily life activities like reading, car driving (in a simulator), and stimulus identification. Not all patients…
(this text is taken from the protocol, see protocol for the detailed version)The main objective of the study is to gain insight in the underlying mechanism of tinnitus suppression. This objective will be achieved by comparing the suppressive effect…
The primary aim of the trial is to assess what the optimal treatment regimen for acetylsalicylic acid, a statin and two BP-lowering agents is (administered as in regular care in individual agents, a fixed-dose combination pill administered in the…
The primary objective of this study is to test the virucidal efficacy of two alcohol based hand disinfectants (according prEN 12791) against murine norovirus 1 (MNV1) and human noroviruses (G1.4 and GII.4) on artificially contaminated hands. The…
The objective of this study is to investigate the effect of broccoli seedlings on postprandial inflammatory parameters and insulin sensitivity after an oral glucose load (dual isotope technique) and monitoring the bioavailability and kinetics of SFN…
-To explore whether no and high dairy consumption have differential effects on health by evaluating markers of glucose, lipid and energy metabolism, oxidation and inflammation, in a fasting and postprandial situation. -To evaluate the potential of…
The purpose of the study is to investigate how quickly and to what extent diclophenac is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP-5000 transdermal patch. Furthermore, the…
The objective of the study is to investigate the effects of beetroot juice, a high nitrate-containing vegetable, on postprandial vascular activity after a high-fat load in overweight and slightly obese male subjects.
Objective: To assess the effect of beer consumption, with a range of alcohol content, on fluid balance after exercise-induced dehydration. Hypothesis: Based on the glucose and electrolyte composition of beer, and the blurred effect of alcohol in the…
1º Is there a significant difference of more than 10% in the pharmacokinetic parameter AUC of the investigated antineoplastic drugs (as a surrogate parameter for the efficacy) in the presence and absence of NNRTIs and/or PIs?2º Are there clinically…
The purpose of the study is to investigate how quickly and to what extent tolterodine is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administrated by using a HP-3040 transdermal patch. Moreover, the relative…