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The effect of a walking bike on exercise capacity in patients with COPD and chronic heart failure

Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…

Effects of acute elevation of plasma free fatty acids on cardiac lipid accumulation in healthy lean young men

The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…

Single-center, open-label study in healthy male subjects to evaluate the absolute bioavailability of a 10 mg oral dose of vericiguat (BAY 1021189) (as IR tablets following a high-fat, high-calorie meal) in comparison to an intravenous, 14C-labeled micro-dose (20 µg) of vericiguat

The primary objective of this study is to evaluate the absolute bioavailability of an oral dose of 10 mg vericiguat (BAY 1021189) given as two 5 mg IR tablets following a high-fat, high calorie meal in comparison to a 14C labeled micro dose of…

Effects of ciprofibrate on myocardial insulin sensitivity in pre-diabetes

The main objective of the study is to investigate whether ciprofibrate treatment can improve myocardial insulin sensitivity in subjects with IGM. As secondary objectives we want to investigate whether ciprofibrate treatment also improves diastolic…

Effect of High-volume Online hemodiafiLtration on intra-diaLytic hemodynAmic (iN)sTability and cardiac function in chronic hemodialysis patients (the HOLLANT study)

This study aims at improving the knowledge concerning HV-HDF and thus helps to tailor the optimal ERRT for each individual patient.The following hypotheses will be tested:1. Intra-dialytic hemodynamic stability is better preserved during HV-HDF as…