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Proof-of-concept study on treating cognitive side-effects of Tamoxifen with guanfacine in postmenopausal women with E2/Pg receptor-positive breast cancer.

Provide proof-of-concept for the hypothesis that guanfacine diminishes cognitive side-effects in ER+ BC patients treated with adjuvant hormonal therapy. Secondary, provide data for power calculations in later studies.

Cognitive effects of nutritional manipulation using the amino acid tyrosine in healthy subjects with ADHD-symptoms

The objective of this experiment is to establish the effects of tyrosine suppletion on cognitive symptoms seen in ADHD. Cognition will be assessed, while simultaneously recording brain activity.

A single-center, randomized, open-label, four-period, four-treatment, cross-over study to investigate the comparative bioavailability of dispersible tablet and capsule formulations of RO5285119 in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent RO5285119 is absorbed from the gut and then eliminated from the body (this is called pharmacokinetics).It will also be investigated to what extent RO5285119 is tolerated.

Pharmacokinetics in Plasma and Saliva of a Single Dose Immediate- or Extended-Release Methylphenidate in Healthy Volunteers.

To establish the pharmacokinetic profiles of saliva and plasma concentration of 10 mg MPH-IR and 18 mg MPH-OROS in healthy volunteers; to investigate whether there is a correlation between saliva- and plasma levels of MPH-IR and MPH-OROS, and if…

A double blind placebo-controlled crossover study to determine the effects of atomoxetine on event-related potentials in response to auditory oddball stimuli during an on-the-road driving test in adult patients with attention-deficit hyperactivity disorder

The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…

Effectiveness of methylphenidate in adults with phenylketonuria and attention-deficit/hyperactivity disorder: An N-of-1 series

Primary Objective: To determine the effectiveness of methylphenidate in reduction of ADHD symptomatology, operationalized by personalized goals that are important to the patient and its environment, in individuals with late-diagnosed PKU. Secondary…

Longer-term effects of wild blueberry consumption on brain function in older men and women

The primary objectives are to investigate in older adults the effect of 16-week wild blueberry consumption on (regional) vascular function and insulin-sensitivity in the brain, while we will also focus on changes in cognitive performance as assessed…

Effects of dialysis duration on brain perfusion and cognitive function in end-stage renal disease - short vs. long hemodialysis

Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…

Promoting independence in bipolar disorder. Does cognitive remediation training of executive functioning lead to an improvement in wellbeing and personal goals of daily functioning?

Goal of the study is to find out if cognitive remediation focused on executive functioning for patients with bipolar disorder improves (1) functioning on personal goals in everyday life? And (2) improves general wellbeing?Hypotheses:Cognitive…

Effects of daily protein supplementation on brain function in older adults with overweight or obesity

The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…