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Feasibility study of a smart ankle foot orthosis in people with paretic ankle muscles

The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…

The Effects of Transcutaneous Vagus Nerve Stimulation on the Pupil Diameter, Heart Rate and Heart Rate Variability in Epilepsy Patients and Healthy Subjects.

Primary objective: The main objective of this pilot study is to gain more insight into the effects of tVNS: to assess if the ABVN and consecutively the NTS are really stimulated by tVNS. Therefore this study investigates the effects of tVNS on the…

A comparative, open-label, randomized, 2-stage sequential design, 2 periods, crossover study to demonstrate the bioequivalence of 2 FT218 batches (single dose of 4.5 gram) in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent 2 different production batches of FT218 (batch A and batch B) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…

An open label, crossover study to investigate the safety and tolerability of Sifrol® (pramipexole) (Boehringer Ingelheim) prolonged release tablets in order to establish the maximum tolerable dose and to assess bioequivalence of Pramipexole prolonged release tablets (Synthon B.V.) compared to Sifrol® prolonged release tablets (Boehringer Ingelheim) in healthy subjects in steady-state conditions

To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.

SINGLE CENTER, OPEN LABEL, RANDOMIZED TWO-WAY CROSSOVER STUDY OF THE EFFECT OF LACOSAMIDE 200MG TWICE DAILY ON THE SINGLE-DOSE PHARMACOKINETICS AND PHARMACODYNAMICS OF WARFARIN (25 MG) IN HEALTHY MALE VOLUNTEERS

Primary objective:The primary objective of this study is to evaluate the effect of LCM 200mg bid on the single dose PK and PD of a single warfarin 25mg dose.Secondary objective:The secondary objective of this study is to monitor the safety and…

Comparing patient's preference of dorsal column stimulation versus dorsal root ganglion stimulation in patients with complex regional pain syndrome confined to the knee

Dorsal column stimulation and dorsal root ganglion stimulation are both proven to be effective as treatment for chronic, neuropathic pain. We want to compare patients preference of stimulation type in patients with chronic, neuropathic pain due to…

Intra-subject reliability of non-invasive brain stimulation on lower limb motor control

The objective is to assess the intra-subject reliability of tDCS induced effects on the reaction time in the lower extremities of healthy subjects.

respiratory muscle activity during mechanical ventilation and spontaneous breathing trials

To optimize ventilator support in critically ill patients admitted to the intensive care unit by monitoring electromyography of the respiratory muscles.

A Randomised Placebo-Controlled Double-blinded High Cervical Epidural Neurostimulation Trial in patients with Intractable Cervicogenic Headache

The primary objective in this study is to evaluate effectiveness of optimized high cervical epidural neurostimulation against placebo-stimulation in patients with intractable cervicogenic headache in a neurostimulation trial.

A multi- center, randomized, cross-over study to demonstrate the efficacy of pudendal neuromodulation for the treatment of neurogenic overactive bladder

The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…

A multiple dose study to evaluate next day effects of MK-4305 on driving performance in healthy non-elderly subjects

The key objective of this study is to assess next-day residual effects of MK-4305 (20 and 40 mg) via driving performance after 1 day of dosing and after 8 days of dosing.

The effects of Transcranial Magnetic Stimulation on freezing in Parkinson's Disease patients with Freezing of Gait

For a possible (better) treatment of FOG a better understanding of the brainmechanism behind this phenomenon is needed. Previous studies showed some brain areas that are possibly involved in FOG.The aim of this study is to see whether we can induce…

A single-site, open-label study in healthy male subjects to compare rotigotine saliva and plasma concentrations in steady-state after multiple-dose application of rotigotine transdermal patch

Primary:To evaluate the feasibility of using unconjugated rotigotine saliva concentrations as a surrogate for unconjugated rotigotine plasma concentrations.Secondary :To evaluate the effect of time of food intake on rotigotine concentrations in…

TEMPUS - The Evening vs Morning Polypill Utilization Study;A randomised controlled cross-over trial to evaluate evening versus morning administration of a cardiovascular polypill

The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…

A randomized, double blind, placebo-controlled crossover study to investigate the effects of a selective serotonergic reuptake inhibitor on resting state fMRI in heathy volunteers.

We propose to conduct a study in healthy subjects where a serotonergic challenge is given in a placebo-controlled, crossover fashion. Before each challenge, participants will be measured 1 time to define their baseline resting state networks (RSNs)…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

A RANDOMIZED, SINGLE-CENTER, OPEN-LABEL, 5-WAY CROSSOVER, SINGLE-DOSE BIOAVAILABILITY/BIOEQUIVALENCE COMPARISON OF BRIVARACETAM ORAL TABLETS (10MG, 50MG, 75MG, AND 100MG) AND BRIVARACETAM INTRAVENOUS BOLUS INJECTION (100MG) IN HEALTHY VOLUNTEERS

Primary objective:To assess the BE under fasted conditions of BRV 10mg, 75mg, and 100mg oral tablets of commercial formulation vs BRV 50mg oral tablet(reference) of clinical development formulation,To assess the BA under fasted conditions of BRV…

Double-blind randomised placebo-controlled cross-over study to investigate the effectiveness of intramuscular magnesium on pain and dystonia in Complex Regional Pain Syndrome type 1

Primary aim of the study is to evaluate the efficacy and safety of intramuscular magnesiumsulphate in CRPS I patients during 3 weeks dose escalation study.

The acute effect of whole body vibration on spasticity of the calf muscle in stroke patients

The purpose of this study is to investigate the acute effects of a single bout of WBV on spasticity of calf muscle in stroke patients.

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…