Search for a trial

TEMPUS - The Evening vs Morning Polypill Utilization Study;A randomised controlled cross-over trial to evaluate evening versus morning administration of a cardiovascular polypill

The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…

Intranasal administration of oxytocin in children with Prader-Willi Syndrome. A randomized, open-label, cross-over trial of different treatment regimens of oxytocin administration. Effects on eating behaviour and social behaviour.

To evaluate the effects of long-term intranasal oxytocin on social behaviour in children with PWS and to compare the effects of different doses and frequencies of oxytocin administration

Accuracy and repeatability of two indirect calorimeters for measuring resting energy expenditure (REE) in adolescents and adults.

Primary objectives: this study will 1) assess the accuracy of the Cortex MetaLyzer® 3B in adolescents (12-17 yr) for measuring REE, using the Deltatrac® II metabolic monitor as a reference; and 2) assess the accuracy and the within-subject, within-…

Critical investigation of the mechanisms at work in EMDR

The aim is to test whether EM in EMDR contributes to a reduction in dysfunctional beliefs about recalling the traumatic memory. A sample of Dutch veterans diagnosed with PTSD will be tested. During three EMDR treatment sessions we will measure…

The effect of meat texture on promoting muscle protein synthesis in elderly humans

The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.

The neurobiological basis of bias and disengagement;
Two neurotransmitter mechanisms implicated in visual spatial attention.

The goal of the current investigation is to test a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the noradrenergic system underlies bias. Two…

Mechanical ventilation comparing high versus low tidal volumes in infants with or without acute lung injury.

The aim of this study is to access the effect of low and high VT (ml/kg) on pulmonary and systemic inflammatory responses and the release of oxygen and nitrogen free radicals in the paediatric patient with and without ALI.

A Prospective, Randomized, Placebo-Controlled Multicenter Study to Evaluate the Performance of the IBV Valve System for the Treatment of Severe Emphysema

The objective of this randomized, blinded, multicenter, controlled study is to compare the performance of the IBV* Valve System (treatment group) to a control group receiving a sham bronchoscopy procedure without valve placement

Stress and Oesophageal Acid Perception

to investigate the relationship between acute psychological stress and perception of acid in the distal oesophagus in healthy volunteers and GORD patients.

Postprandial amino acid profiles and gastric protein coagulation after consumption of milk and plant-based alternatives: an exploratory study.

To explore the effect of additional protein in plant-based drinks. In addition, gastric protein coagulation will be examined for one of the plant-based drinks and compared to that of bovine milk.

Markers of Oxidative Stress from Supplemental Oxygen in critically-ill children

This study has two parts. The main objective of part 1 (in vivo) is todetermine changes in markers of oxidative stress in exhaled breath as a result of different short term oxygenation strategies (liberal versus conservative) . The main objective of…