30 results
Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…
Healthy volunteers and patients with a high variability in pain scores have a high probability to experience pain relief from alfentanil opposed to volunteers and patients with a low variability in pain scores.
Objective: The overall aim of this project is to investigate acute effects of moderate- and high-intensity exercise in heart failure patients and their age- and sex-matched controls on brachial artery shear patterns.
The main objective is to investigate whether high frequency low dosage IVIg treatment is more effective than low frequency high dosage as maintenance treatment for CIDP. The secondary objective is to investigate whether high frequency low dosage of…
Oral exposure time and energy content of the gastric load both affect subjective feelings of satiety and gastric emptying rate. It is expected that a longer oral exposure time and a higher gastric energy content would both increase subjective…
Patients will prefer power scalers over hand instruments.
It is hypothesized that foods that have an intrinsic nutrient-rich matrix are less susceptible to changes in reward value due to replacing the sugar content than foods that have intrinsic a nutrient-empty matrix. Thus we expect that the reward value…
Amlodipine is prescribed off-label for paediatric patients, but there is no safe, efficacious and appropriate paediatric formulation available. Therefore, an appropriate amlodipine besilate oral liquid 0,5 mg/ml is developed. In order to establish…
1. The deafferentiation during spinal anesthesia changes the connectivity in resting-state networks in healthy volunteers; 2. The deafferentiation during spinal anesthesia changes pain perception and has sedetive effects.
During treatment with dexamethasone, the deprived mineralocorticoid receptor may cause serious cerebral side effects. Hence, it is feasible that these side effects on mood, behaviour and cognition could be prevented, by an intervention with a…
Diabetes specific oral nutritional supplement has an improved 4-hour postprandial glucose response compared to standard oral nutritional supplement.
N/A
By introducing of PK-guided individualized dosing of pazopanib we hypothesize that the interpatient variability can be reduced by 50%.
To demonstrate proof of principle for the elimination of malaria from Rusinga Island using the nation-wide adopted strategy of LLINs and case management augmented with mass trapping of mosquito vectors.
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
The goal of the study is to: 1. Improve daily functioning in patients with schizophrenia; 2. To improve behavioral observation in psychiatric nurses; 3. To implement CAT in the usual treatment of patients with severe mental illness.
1. Evaluation of pulmonary deposition of inhaled Tobramycin with 99mTc-DTPA tracer is feasible using SPECT-CT scans; 2a. Pulmonary deposition of Tobramycin improves with concomitant inhalation of carbon dioxide enriched ambient air; 2b. Pulmonary…
We hypothesize that in this short term study the testproducts with added fibre will increase satiety, slower gastric emptying, will give a later blood glucose peak and that it will decrease energy intake when compared to the controlproduct.
The present study will investigate: 1. Whether drug-related cues activate the same neural networks as does the administration of the drug itself; 2. The implicit and explicit associations of alcohol and cannabis users; 3. The effect of acute doses…