21 results
To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.
To determine the effect of a high-fat meal on the exposure to docetaxel given as ModraDoc006 tablets in combination with ritonavir in patients with cancer.
The primary objective is to investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in T2DM individuals and to unravel molecular mechanisms underlying effects of natural daylight on circadian clocks and (…
To investigate the influence of air temperature and humidity on the occurrence of EILO. A better understanding of the pathophysiologic principles causing EILO could lead to increased sensitivity of CLE testing. New insights in the causes of EILO can…
The main objective of study 1 is to test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in a cross-over design in 50 remitted MDD patients vulnerable for depressive relapse. The…
The main objective of this study is to determine the performance of the closed-loop system in adolescents with T1DM. Secondary objectives include: • to assess the safety of the closed-loop system; • to determine the time that the closed-loop…
In this study we will investigate what the effect of food is on how the study compound PTC518 is absorbed, transported, and eliminated from the body.We will also investigate how safe the new compound PTC518 is and how well it is tolerated when it is…
The primary objective of this pilot study is to investigate the feasibility of an intervention based on the Arm Activity Tracker that aims to increase arm use during daily life conditions in stroke patients. Secondary objective is to obtain…
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
To quantify fructose that escapes the portal circulation and appears in the systemic circulation, by measuring serum fructose using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) within 150 minutes following intake of…
To assess the effect of enteral feeding with higher protein content compared to standard protein content on indicator amino acid oxidation in ICU patients.
The aim of this study is to investigate in salt-sensitive kidney patients the effect of two different dietary sodium regimens on BP and body fluid volume. Furthermore, we aim to evaluate the way in which new sodium handling mechanisms (interstitial…
To determine the food-effect of a standardised Dutch breakfast on the pharmacokinetics of oral alectinib (Alecensa®), especially Cmax, AUC and relative bioavailability, at steady state using a stable isotopically labelled microtracer approach.
The primary objective of this study is the pain tolerance of linear increasing electric stimuli between music and control setting (podcast), especially looking at the social background. Moreover, comparison of the two music interventions, self-…
The objectives of the study are to:A. Determine the effects of music therapy during skin-breaking procedures on the pain response in infants admitted to a NICU or HC ward.B. Determine the effects of music therapy during skin-breaking procedures on…
To investigate the impact of different doses of handgrip exercises (moderate vs high intensity) and stimuli (exercise vs ischemia) on the ability to protect endothelial damage from ischemia-reperfusion injury in healthy humans. A secondary goal is…
Primary Objective: To determine the difference in change in sputum viscoelasticity on HME and HFTO during disconnection sessions from the ventilator in tracheotomised patients. Secondary Objective(s): 1. To determine the difference in respiratory…
This study aims to answer the following questions: 1. Is there a difference in the time to onset of the first symptom between HH and NH?2. Is there a difference in the severity of symptoms between HH and NH?3. Is there a difference in the time to…
By using advanced respiratory monitoring, we will aim to gain more understanding about the physiological effects and potential benefits of FCV in comparison to VCV in patients with an exacerbation of their asthma or COPD. We hypothesize that FCV in…
The present study compares the postprandial amino acid uptake kinetics between a commercially available (fermented) yoghurt vs a commercially available (pasteurized) milk matched for protein, and small differences on fat, calories, and volume.