20 results
To determine the mechanism of action of propranolol in the prophylactic treatment of migraine.
To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.
We aim to assess the effects of tyrosine supplementation on prefrontal brain activation, as measured by a combination of fNIRS and EEG, during response inhibition and working-memory performance in older adults. We will also assess whether…
To determine the effect of a high-fat meal on the exposure to docetaxel given as ModraDoc006 tablets in combination with ritonavir in patients with cancer.
The primary aim is to validate the finding that addition of physiological doses of hydrocortisone reduces dexamethasone-induced clinically relevant neurobehavioral problems. The secondary aims are to study the role of genetic variation, psychosocial…
To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.
The main objective of this study is to determine the performance of the closed-loop system in adolescents with T1DM. Secondary objectives include: • to assess the safety of the closed-loop system; • to determine the time that the closed-loop…
In this study we will investigate what the effect of food is on how the study compound PTC518 is absorbed, transported, and eliminated from the body.We will also investigate how safe the new compound PTC518 is and how well it is tolerated when it is…
The primary objective of this pilot study is to investigate the feasibility of an intervention based on the Arm Activity Tracker that aims to increase arm use during daily life conditions in stroke patients. Secondary objective is to obtain…
The aim of this project is to assess the acute effects of the N-methyl-D-aspartate receptor antagonist S(+)-Ketamine compared to placebo on body and self-perception, using cognitive experimental tasks and EEG in healthy volunteers.
Primary objectiveThe primary objective is to determine whether 3-MMC can be safely administered in healthy volunteers in doses up to 100 mg. Participants will be monitored by a medical doctor and vital signs, laboratory safety and side effects will…
This study consists of the following objections:- To evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham)- To evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks (compared…
Part A (Single Ascending Dose):Primary: To assess the safety and tolerability of single oral doses of PRAX-628 Secondary: To evaluate the pharmacokinetics (PK) of single oral doses of PRAX-628 Part B (Multiple Ascending Dose):Primary: To assess the…
The purpose of the INTIBIA pivotal study is to demonstrate the safety and effectiveness of the INTIBIA System in the intended population through 24 months of follow-up. Data at 12-months will be used to support regulatory approval.The objective of…
Asses whether, in patients with heart failure with preserved ejection fraction and iron deficiency, ferric carboxymaltose improves leftventricular diastolic function and skeletal muscle function by improving energy metabolism
Main objective of this study is to characterize the possible benefits of the new Phonak Marvel CI-CROS device on speech understanding in noise, including its implemented beamformers (UltraZoom and StereoZoom) using different noise setups.
To determine the food-effect of a standardised Dutch breakfast on the pharmacokinetics of oral alectinib (Alecensa®), especially Cmax, AUC and relative bioavailability, at steady state using a stable isotopically labelled microtracer approach.
Primary Objective: To determine the difference in change in sputum viscoelasticity on HME and HFTO during disconnection sessions from the ventilator in tracheotomised patients. Secondary Objective(s): 1. To determine the difference in respiratory…
Transiently improve episodic memory in early AD patients with precuneal gamma (40 Hz) tACS (main objective) and identify what functional brain activity/network changes underlie this memory improvement (secondary objective)
The present study compares the postprandial amino acid uptake kinetics between a commercially available (fermented) yoghurt vs a commercially available (pasteurized) milk matched for protein, and small differences on fat, calories, and volume.